Compound Detail
CHEMBL5809136
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Basic Information
| ChEMBL ID | CHEMBL5809136 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VEWKBTTWHTZHER-JGVFFNPUSA-N |
7
Targets
21
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
226.1
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 21 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Presequence protease, mitochondrial CHEMBL3124731 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| Dipeptidyl peptidase 9 CHEMBL4793 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Dipeptidyl peptidase 8 CHEMBL4657 | IC50 | 5.25 | 5.25 | 5600.0 | 1 |
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 4.47 | 4.47 | 34000.0 | 1 |
| Dipeptidyl peptidase 8/9 CHEMBL3885564 | IC50 | 4.26 | 4.26 | 55000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 200.0 | nM | 6.7 | EnPlex (purified enzyme activity assay): This assay is described in Bachovchin e... | - |
| Presequence protease, mitochondrial | IC50 | = | 200.0 | nM | 6.7 | In Vitro Inhibition Assay: Materials: Enzymes Recombinant human DPPIV (R&D Syste... | - |
| Dipeptidyl peptidase 4 | IC50 | = | 1400.0 | nM | 5.85 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 9 | IC50 | = | 1500.0 | nM | 5.82 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 8 | IC50 | = | 5600.0 | nM | 5.25 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 2 | IC50 | = | 34000.0 | nM | 4.47 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
| Dipeptidyl peptidase 8/9 | IC50 | = | 55000.0 | nM | 4.26 | In Vitro Inhibition Assay: EnzymesRecombinant human DPPIV (R&D Systems, Cat. No.... | - |
Data from ChEMBL 36 via Core Engine