Compound Detail
CHEMBL5817923
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5817923 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UJCYGTTWTLTIEZ-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
507.6
MW (Da)
4.50
ALogP
8
HBA
2
HBD
78.4
PSA (Ų)
0.52
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 4 CHEMBL331 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Cyclin-dependent kinase 6 CHEMBL2508 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
| CDK2/Cyclin A2 CHEMBL3038469 | IC50 | 7.01 | 7.01 | 97.0 | 1 |
| Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B CHEMBL6066545 | IC50 | 6.34 | 6.34 | 453.0 | 1 |
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 5.66 | 5.66 | 2215.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 4.47 | 4.47 | 33705.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 4 | IC50 | = | 9.0 | nM | 8.05 | In Vitro Kinase Inhibition Assay: CDK4 and CDK6: IC50 values of compounds agains... | - |
| Cyclin-dependent kinase 6 | IC50 | = | 27.0 | nM | 7.57 | In Vitro Kinase Inhibition Assay: CDK4 and CDK6: IC50 values of compounds agains... | - |
| CDK2/Cyclin A2 | IC50 | = | 97.0 | nM | 7.01 | Z′-LYTE Assay: CDK5 (p25): IC50 values of compounds against CDK5 (p25) were dete... | - |
| Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B | IC50 | = | 453.0 | nM | 6.34 | In Vitro Kinase Inhibition Assay: CDK1 (cyclin B): IC50 values of compounds agai... | - |
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 2215.0 | nM | 5.66 | LanthaScreen Eu Kinase Binding Assay: FMS: IC50 values of compounds against FMS ... | - |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 33705.0 | nM | 4.47 | Activity Assay: PI3Kδ: Briefly, this assay was conducted in buffer (Tris-HCl 40 ... | - |
Data from ChEMBL 36 via Core Engine