Compound Detail
CHEMBL68956
SUKSDORFIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL68956 |
| Name | SUKSDORFIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KLUTZDJBVDPOFE-WOJBJXKFSA-N |
4
Targets
6
Activities
2
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
388.4
MW (Da)
3.53
ALogP
7
HBA
0
HBD
92.0
PSA (Ų)
0.58
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas. best 5.89
IC50 2 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Human immunodeficiency virus 1 CHEMBL378 | EC50 | 5.89 | 5.735 | 1300.0 | 2 |
| Human immunodeficiency virus CHEMBL613758 | EC50 | 5.89 | 5.89 | 1300.0 | 1 |
| H9 CHEMBL614806 | EC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Human immunodeficiency virus 1 CHEMBL378 | IC50 | 5.58 | 5.58 | 2600.0 | 1 |
| Mus musculus CHEMBL375 | IC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| H9 | EC50 | = | 1300.0 | nM | 5.89 | Effective concentration against HIV-1 replication in H9 lymphocyte cells was det... | - |
| Human immunodeficiency virus | EC50 | = | 1300.0 | nM | 5.89 | Antiviral activity against HIV | 14987069 |
| Human immunodeficiency virus 1 | EC50 | = | 1300.0 | nM | 5.89 | Antiviral activity against HIV1 3B infected in H9 cells assessed as inhibition o... | 20187635 |
| Human immunodeficiency virus 1 | EC50 | = | 2600.0 | nM | 5.58 | Anti-HIV activity in acutely infected H9 lymphocytes. | 7525962 |
| Human immunodeficiency virus 1 | IC50 | = | 2600.0 | nM | 5.58 | Antiviral activity against HIV1 3B infected in human H9 cells after 4 days by EL... | 28850227 |
| Mus musculus | IC50 | = | 11000.0 | nM | 4.96 | Inhibitory activity against LPS-induced NO production in mouse peritoneal macrop... | 9873511 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9873511 | 10.1016/s0960-894x(98)00391-6 | Rattus norvegicus | 2 |
| 7525962 | 10.1021/jm00049a014 | Human immunodeficiency virus 1 | 2 |
| - | 10.1016/S0960-894X(01)80161-X | H9 | 2 |
| 9873511 | 10.1016/s0960-894x(98)00391-6 | Mus musculus | 1 |
| - | 10.1016/S0960-894X(01)80161-X | ADMET | 1 |
| 14987069 | 10.1021/np030373o | Human immunodeficiency virus | 1 |
| 20187635 | 10.1021/np900821e | Human immunodeficiency virus 1 | 1 |
| 20187635 | 10.1021/np900821e | ADMET | 1 |
| 28850227 | 10.1021/acs.jmedchem.7b00315 | Human immunodeficiency virus 1 | 1 |
Data from ChEMBL 36 via Core Engine