Compound Detail
CHEMBL95606
CYTIDINE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL95606 |
| Name | CYTIDINE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | UHDGCWIWMRVCDJ-XVFCMESISA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
20
Publications
3
Known Names
5
Indications
Molecular Properties
243.2
MW (Da)
-2.56
ALogP
8
HBA
4
HBD
130.8
PSA (Ų)
0.45
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Indications
Cataract Bipolar Disorder Keratoconus Prognathism Carcinoma, Non-Small-Cell Lung
Activity Summary
IC50 4 meas. best 5.37
EC50 2 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | EC50 | 6.42 | 6.42 | 385.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.37 | 5.02 | 4270.0 | 4 |
| Hepatitis C virus CHEMBL379 | EC50 | 4.3 | 4.3 | 50000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | EC50 | = | 385.0 | nM | 6.42 | MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). | - |
| Unchecked | IC50 | = | 4270.0 | nM | 5.37 | MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultiva... | - |
| Unchecked | IC50 | = | 7310.0 | nM | 5.14 | MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultiva... | - |
| Unchecked | IC50 | = | 14090.0 | nM | 4.85 | MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultiva... | - |
| Unchecked | IC50 | = | 19130.0 | nM | 4.72 | MMV: Anti-babesial activity assay. Parasite pRBCs at 1% parasitemia were cultiva... | - |
| Hepatitis C virus | EC50 | = | 50000.0 | nM | 4.3 | Antiviral activity against HCV by replicon assay | 35123007 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL3301486 | Unchecked | 8 |
| - | 10.6019/CHEMBL3301472 | Human immunodeficiency virus 1 | 7 |
| - | 10.6019/CHEMBL3301472 | NON-PROTEIN TARGET | 6 |
| - | 10.6019/CHEMBL3137381 | Onchocerca lienalis | 4 |
| - | 10.6019/CHEMBL3301464 | Unchecked | 4 |
| - | 10.6019/CHEMBL3301546 | Saccharomyces cerevisiae | 3 |
| 17101674 | 10.1128/aac.00400-06 | Deoxycytidine kinase | 3 |
| 17101674 | 10.1128/aac.00400-06 | Uridine-cytidine kinase 1 | 3 |
| - | 10.6019/CHEMBL2363022 | Schistosoma mansoni | 3 |
| 17999967 | 10.1128/aac.01184-07 | Cytidine deaminase | 3 |
| 3981534 | 10.1021/jm00382a006 | L1210 | 2 |
| - | 10.6019/CHEMBL2094260 | Mycobacterium tuberculosis | 2 |
| - | 10.6019/CHEMBL3301451 | Plasmodium falciparum | 2 |
| 15844957 | 10.1021/np0495985 | NON-PROTEIN TARGET | 2 |
| - | 10.6019/CHEMBL3301458 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 2 |
| - | 10.1021/np50060a041 | Ileum | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 1895307 | 10.1021/jm00113a034 | PC-13 | 1 |
| 1895307 | 10.1021/jm00113a034 | QG-56 | 1 |
| 35123007 | 10.1016/j.bmcl.2022.128605 | Hepatitis C virus | 1 |
Data from ChEMBL 36 via Core Engine