Assay Detail
Binding
CHEMBL1909158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)
1742
Total Activities
871
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
DrugMatrix in vitro pharmacology data
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 871 | 7.94 | 10.07 |
| Ki | 871 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1477 | CERIVASTATIN | 4.0 | 2 | 10.07 |
| CHEMBL1487 | ATORVASTATIN | 4.0 | 2 | 9.64 |
| CHEMBL2220442 | FLUVASTATIN | 4.0 | 2 | 9.45 |
| CHEMBL1064 | SIMVASTATIN | 4.0 | 2 | 8.47 |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 2 | 8.25 |
| CHEMBL503 | LOVASTATIN | 4.0 | 2 | 7.70 |
| CHEMBL54440 | MEVASTATIN | 2.0 | 2 | 6.92 |
| CHEMBL506247 | TANNIC ACID | 4.0 | 2 | 5.50 |
| CHEMBL1729 | CISAPRIDE | 4.0 | 2 | 5.47 |
| CHEMBL1077 | BROMFENAC | 4.0 | 2 | - |
| CHEMBL894 | BUPROPION | 4.0 | 2 | - |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 2 | - |
| CHEMBL277474 | ANTIPYRINE | 3.0 | 2 | - |
| CHEMBL24 | ATENOLOL | 4.0 | 2 | - |
| CHEMBL1598608 | AZASETRON | 2.0 | 2 | - |
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 2 | - |
| CHEMBL31184 | BENZO[DEF]CHRYSENE | 0.5 | 2 | - |
| CHEMBL415690 | BETADEX | 3.0 | 2 | - |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 2 | - |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 2 | - |
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 2 | - |
| CHEMBL221753 | BENZETHONIUM CHLORIDE | 2.0 | 2 | - |
| CHEMBL701 | BACLOFEN | 4.0 | 2 | - |
| CHEMBL1095699 | AZASERINE | 2.0 | 2 | - |
| CHEMBL3084803 | ASTROMICIN | 2.0 | 2 | - |
| CHEMBL211501 | ANTIMYCIN A | — | 2 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 2 | - |
| CHEMBL1458880 | CADMIUM DICHLORIDE | — | 2 | - |
| CHEMBL1200396 | BUPIVACAINE HYDROCHLORIDE | 4.0 | 2 | - |
| CHEMBL844 | BRIMONIDINE | 4.0 | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1477 | CERIVASTATIN | IC50 | = | 0.085 | nM | 10.07 |
| CHEMBL1487 | ATORVASTATIN | IC50 | = | 0.227 | nM | 9.64 |
| CHEMBL2220442 | FLUVASTATIN | IC50 | = | 0.353 | nM | 9.45 |
| CHEMBL1064 | SIMVASTATIN | IC50 | = | 3.39 | nM | 8.47 |
| CHEMBL1144 | PRAVASTATIN | IC50 | = | 5.591 | nM | 8.25 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL54440 | MEVASTATIN | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL506247 | TANNIC ACID | IC50 | = | 3127.0 | nM | 5.50 |
| CHEMBL1729 | CISAPRIDE | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL91 | MICONAZOLE | Ki | - | — | - | |
| CHEMBL80 | NALOXONE | IC50 | - | — | - | |
| CHEMBL80 | NALOXONE | Ki | - | — | - | |
| CHEMBL1513 | IRBESARTAN | IC50 | - | — | - | |
| CHEMBL1513 | IRBESARTAN | Ki | - | — | - | |
| CHEMBL6067487 | IVERMECTIN | IC50 | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | IC50 | - | — | - | |
| CHEMBL741 | LAMOTRIGINE | IC50 | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | IC50 | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | Ki | - | — | - | |
| CHEMBL91 | MICONAZOLE | IC50 | - | — | - | |
| CHEMBL878 | METOLAZONE | Ki | - | — | - | |
| CHEMBL878 | METOLAZONE | IC50 | - | — | - | |
| CHEMBL313493 | METHANESULFONIC ACID METHYL ESTER | Ki | - | — | - | |
| CHEMBL313493 | METHANESULFONIC ACID METHYL ESTER | IC50 | - | — | - | |
| CHEMBL19215 | METERGOLINE | Ki | - | — | - | |
| CHEMBL19215 | METERGOLINE | IC50 | - | — | - | |
| CHEMBL164290 | N-NITROSODIETHYLAMINE | Ki | - | — | - | |
| CHEMBL503 | LOVASTATIN | Ki | - | — | - | |
| CHEMBL1909064 | LIPOPOLYSACCHARIDE E. COLI O55:B5 | Ki | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | IC50 | - | — | - | |
| CHEMBL1201237 | LEVOBUNOLOL | IC50 | - | — | - | |
| CHEMBL975 | MESNA | Ki | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | IC50 | - | — | - | |
| CHEMBL86304 | MOCLOBEMIDE | Ki | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | IC50 | - | — | - | |
| CHEMBL1630579 | MYRTECAINE | Ki | - | — | - | |
| CHEMBL19019 | NALTREXONE | IC50 | - | — | - | |
| CHEMBL19019 | NALTREXONE | Ki | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | IC50 | - | — | - | |
| CHEMBL1354199 | METHSCOPOLAMINE BROMIDE | Ki | - | — | - | |
| CHEMBL2106399 | KITASAMYCIN | IC50 | - | — | - | |
| CHEMBL86 | METOCLOPRAMIDE | Ki | - | — | - | |
| CHEMBL6437 | MIANSERIN | IC50 | - | — | - | |
| CHEMBL6437 | MIANSERIN | Ki | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | IC50 | - | — | - | |
| CHEMBL1618305 | NALOXONAZINE | Ki | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | Ki | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | IC50 | - | — | - | |
| CHEMBL64391 | ITRACONAZOLE | Ki | - | — | - |