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Assay Detail

CHEMBL1963687

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCQ
ChEMBL ↗
336
Total Activities
326
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein kinase C theta type (CHEMBL3920) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 336 6.07 9.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1996510 — — 1 9.50
CHEMBL565612 SOTRASTAURIN 2.0 1 9.20
CHEMBL1973720 — — 2 9.10
CHEMBL360847 — — 1 8.80
CHEMBL1980995 — — 1 8.70
CHEMBL1981133 — — 1 8.50
CHEMBL1980407 — — 1 8.40
CHEMBL2002992 — — 1 8.10
CHEMBL1969151 — — 1 8.10
CHEMBL2000029 — — 1 7.90
CHEMBL1986943 — — 2 7.80
CHEMBL225519 — — 1 7.40
CHEMBL1993661 — — 1 7.20
CHEMBL1965660 — — 2 7.20
CHEMBL1990254 — — 1 7.20
CHEMBL1967878 CENISERTIB 2.0 1 7.20
CHEMBL422897 — — 1 7.10
CHEMBL1994526 — — 1 7.10
CHEMBL1991674 — — 1 7.00
CHEMBL1870106 — — 1 7.00
CHEMBL1975121 — — 1 6.90
CHEMBL1988581 — — 1 6.90
CHEMBL1967252 — — 1 6.90
CHEMBL2007574 — — 1 6.90
CHEMBL1982711 — — 1 6.80
CHEMBL2006299 — — 1 6.70
CHEMBL1992073 — — 1 6.70
CHEMBL1970290 — — 1 6.60
CHEMBL1973359 — — 1 6.60
CHEMBL1977138 — — 1 6.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1996510 — Ki = 0.3162 nM 9.50
CHEMBL565612 SOTRASTAURIN Ki = 0.631 nM 9.20
CHEMBL1973720 — Ki = 0.7943 nM 9.10
CHEMBL1973720 — Ki = 0.7943 nM 9.10
CHEMBL360847 — Ki = 1.585 nM 8.80
CHEMBL1980995 — Ki = 1.995 nM 8.70
CHEMBL1981133 — Ki = 3.162 nM 8.50
CHEMBL1980407 — Ki = 3.981 nM 8.40
CHEMBL1969151 — Ki = 7.943 nM 8.10
CHEMBL2002992 — Ki = 7.943 nM 8.10
CHEMBL2000029 — Ki = 12.59 nM 7.90
CHEMBL1986943 — Ki = 15.85 nM 7.80
CHEMBL1986943 — Ki = 15.85 nM 7.80
CHEMBL225519 — Ki = 39.81 nM 7.40
CHEMBL1965660 — Ki = 63.1 nM 7.20
CHEMBL1993661 — Ki = 63.1 nM 7.20
CHEMBL1965660 — Ki = 63.1 nM 7.20
CHEMBL1967878 CENISERTIB Ki = 63.1 nM 7.20
CHEMBL1990254 — Ki = 63.1 nM 7.20
CHEMBL1994526 — Ki = 79.43 nM 7.10
CHEMBL422897 — Ki = 79.43 nM 7.10
CHEMBL1991674 — Ki = 100.0 nM 7.00
CHEMBL1870106 — Ki = 100.0 nM 7.00
CHEMBL1975121 — Ki = 125.89 nM 6.90
CHEMBL1967252 — Ki = 125.89 nM 6.90
CHEMBL2007574 — Ki = 125.89 nM 6.90
CHEMBL1988581 — Ki = 125.89 nM 6.90
CHEMBL1982711 — Ki = 158.49 nM 6.80
CHEMBL2006299 — Ki = 199.53 nM 6.70
CHEMBL1992073 — Ki = 199.53 nM 6.70
CHEMBL1973359 — Ki = 251.19 nM 6.60
CHEMBL1970290 — Ki = 251.19 nM 6.60
CHEMBL1977138 — Ki = 316.23 nM 6.50
CHEMBL1980329 — Ki = 316.23 nM 6.50
CHEMBL1994724 — Ki = 316.23 nM 6.50
CHEMBL1989043 — Ki = 316.23 nM 6.50
CHEMBL1972355 — Ki = 398.11 nM 6.40
CHEMBL1084546 PF-00562271 Ki = 398.11 nM 6.40
CHEMBL1974328 — Ki = 398.11 nM 6.40
CHEMBL1991734 — Ki = 398.11 nM 6.40
CHEMBL1081312 — Ki = 501.19 nM 6.30
CHEMBL2007421 — Ki = 501.19 nM 6.30
CHEMBL1983945 — Ki = 501.19 nM 6.30
CHEMBL2004637 — Ki = 501.19 nM 6.30
CHEMBL38380 FASUDIL Ki = 630.96 nM 6.20
CHEMBL2003514 — Ki = 630.96 nM 6.20
CHEMBL38380 FASUDIL Ki = 630.96 nM 6.20
CHEMBL379975 — Ki = 630.96 nM 6.20
CHEMBL1978195 — Ki = 630.96 nM 6.20
CHEMBL1995211 — Ki = 630.96 nM 6.20