Compound Detail
CHEMBL1994724
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Basic Information
| ChEMBL ID | CHEMBL1994724 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SJLQDZDKTVBBLP-UHFFFAOYSA-N |
16
Targets
16
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
338.4
MW (Da)
4.31
ALogP
4
HBA
1
HBD
51.2
PSA (Ų)
0.75
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 16 meas. best 8.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rho-associated protein kinase 1 CHEMBL3231 | Ki | 8.9 | 8.9 | 1.3 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha CHEMBL4101 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Aurora kinase A CHEMBL4722 | Ki | 6.7 | 6.7 | 199.5 | 1 |
| Protein kinase C theta type CHEMBL3920 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Ki | 6.5 | 6.5 | 316.2 | 1 |
| Aurora kinase B CHEMBL2185 | Ki | 6.4 | 6.4 | 398.1 | 1 |
| Glycogen synthase kinase-3 alpha CHEMBL2850 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| G protein-coupled receptor kinase 5 CHEMBL5678 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Glycogen synthase kinase-3 beta CHEMBL262 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Ribosomal protein S6 kinase alpha-3 CHEMBL2345 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Casein kinase I isoform alpha CHEMBL2793 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| cAMP-dependent protein kinase catalytic subunit PRKX CHEMBL5818 | Ki | 5.7 | 5.7 | 1995.3 | 1 |
| Activin receptor type-1 CHEMBL5903 | Ki | 5.6 | 5.6 | 2511.9 | 1 |
| Cyclin-dependent kinase 8 CHEMBL5719 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
| Mitogen-activated protein kinase kinase kinase kinase 4 CHEMBL6166 | Ki | 5.3 | 5.3 | 5011.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Data from ChEMBL 36 via Core Engine