Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1963789

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GPRK5
ChEMBL ↗
356
Total Activities
346
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

G protein-coupled receptor kinase 5 (CHEMBL5678) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 356 5.54 7.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 7.60
CHEMBL1980407 — — 1 7.40
CHEMBL1988581 — — 1 7.10
CHEMBL1988141 — — 1 7.10
CHEMBL1973359 — — 1 6.80
CHEMBL2007574 — — 1 6.70
CHEMBL1996510 — — 1 6.60
CHEMBL1995811 — — 1 6.60
CHEMBL509032 TAE-684 — 1 6.50
CHEMBL21156 — — 1 6.40
CHEMBL2002099 — — 2 6.40
CHEMBL1985681 — — 1 6.40
CHEMBL1992073 — — 1 6.40
CHEMBL1991078 — — 1 6.40
CHEMBL461876 — — 1 6.30
CHEMBL1972346 — — 1 6.30
CHEMBL1980329 — — 1 6.30
CHEMBL1972355 — — 1 6.20
CHEMBL2002992 — — 1 6.20
CHEMBL1973720 — — 2 6.20
CHEMBL1421720 — — 1 6.20
CHEMBL1983111 — — 1 6.20
CHEMBL565612 SOTRASTAURIN 2.0 1 6.20
CHEMBL1969151 — — 1 6.20
CHEMBL1977138 — — 1 6.10
CHEMBL1997335 — — 1 6.10
CHEMBL2002723 — — 1 6.10
CHEMBL1973936 — — 1 6.10
CHEMBL1984296 — — 1 6.10
CHEMBL1980391 RG-1530 1.0 1 6.10

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 25.12 nM 7.60
CHEMBL1980407 — Ki = 39.81 nM 7.40
CHEMBL1988141 — Ki = 79.43 nM 7.10
CHEMBL1988581 — Ki = 79.43 nM 7.10
CHEMBL1973359 — Ki = 158.49 nM 6.80
CHEMBL2007574 — Ki = 199.53 nM 6.70
CHEMBL1995811 — Ki = 251.19 nM 6.60
CHEMBL1996510 — Ki = 251.19 nM 6.60
CHEMBL509032 TAE-684 Ki = 316.23 nM 6.50
CHEMBL1985681 — Ki = 398.11 nM 6.40
CHEMBL21156 — Ki = 398.11 nM 6.40
CHEMBL2002099 — Ki = 398.11 nM 6.40
CHEMBL1991078 — Ki = 398.11 nM 6.40
CHEMBL1992073 — Ki = 398.11 nM 6.40
CHEMBL461876 — Ki = 501.19 nM 6.30
CHEMBL1972346 — Ki = 501.19 nM 6.30
CHEMBL1980329 — Ki = 501.19 nM 6.30
CHEMBL565612 SOTRASTAURIN Ki = 630.96 nM 6.20
CHEMBL1983111 — Ki = 630.96 nM 6.20
CHEMBL1421720 — Ki = 630.96 nM 6.20
CHEMBL2002992 — Ki = 630.96 nM 6.20
CHEMBL1973720 — Ki = 630.96 nM 6.20
CHEMBL1969151 — Ki = 630.96 nM 6.20
CHEMBL1973720 — Ki = 630.96 nM 6.20
CHEMBL1972355 — Ki = 630.96 nM 6.20
CHEMBL1980391 RG-1530 Ki = 794.33 nM 6.10
CHEMBL1973936 — Ki = 794.33 nM 6.10
CHEMBL1997335 — Ki = 794.33 nM 6.10
CHEMBL2002723 — Ki = 794.33 nM 6.10
CHEMBL1984296 — Ki = 794.33 nM 6.10
CHEMBL1977138 — Ki = 794.33 nM 6.10
CHEMBL191003 JNJ-7706621 Ki = 1000.0 nM 6.00
CHEMBL1994724 — Ki = 1000.0 nM 6.00
CHEMBL1991734 — Ki = 1000.0 nM 6.00
CHEMBL1997193 — Ki = 1000.0 nM 6.00
CHEMBL259084 MLN-8054 Ki = 1000.0 nM 6.00
CHEMBL1983980 — Ki = 1000.0 nM 6.00
CHEMBL2002099 — Ki = 1000.0 nM 6.00
CHEMBL1992125 — Ki = 1000.0 nM 6.00
CHEMBL1993661 — Ki = 1000.0 nM 6.00
CHEMBL1992042 — Ki = 1258.93 nM 5.90
CHEMBL1980167 — Ki = 1258.93 nM 5.90
CHEMBL1970290 — Ki = 1258.93 nM 5.90
CHEMBL1974480 — Ki = 1258.93 nM 5.90
CHEMBL1970352 — Ki = 1258.93 nM 5.90
CHEMBL1978371 — Ki = 1258.93 nM 5.90
CHEMBL1986943 — Ki = 1584.89 nM 5.80
CHEMBL1982711 — Ki = 1584.89 nM 5.80
CHEMBL1975923 — Ki = 1584.89 nM 5.80
CHEMBL1983575 — Ki = 1584.89 nM 5.80