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Assay Detail

CHEMBL1963721

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ACVR1
ChEMBL ↗
357
Total Activities
346
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Activin receptor type-1 (CHEMBL5903) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 357 5.90 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL49120 PD-0166285 1.0 1 8.80
CHEMBL1996702 — — 1 8.50
CHEMBL509032 TAE-684 — 1 8.00
CHEMBL550418 — — 1 7.80
CHEMBL1983923 — — 1 7.50
CHEMBL1976420 — — 1 7.40
CHEMBL1983715 — — 1 7.40
CHEMBL1967878 CENISERTIB 2.0 1 7.40
CHEMBL1983575 — — 1 7.40
CHEMBL1999484 — — 1 7.40
CHEMBL1999414 — — 1 7.30
CHEMBL101311 — — 1 7.30
CHEMBL1980995 — — 1 7.20
CHEMBL406845 — — 1 7.20
CHEMBL2001987 — — 1 7.20
CHEMBL1081312 — — 1 7.20
CHEMBL50894 ALSTERPAULLONE — 1 7.20
CHEMBL5416410 DASATINIB 4.0 1 7.10
CHEMBL1972220 — — 1 7.00
CHEMBL1994555 — — 1 7.00
CHEMBL379975 — — 1 7.00
CHEMBL1996649 — — 1 7.00
CHEMBL1979690 — — 1 7.00
CHEMBL1967998 — — 1 6.90
CHEMBL1981215 — — 1 6.90
CHEMBL1987998 — — 1 6.90
CHEMBL1986756 — — 1 6.90
CHEMBL1988581 — — 1 6.90
CHEMBL1981047 — — 1 6.90
CHEMBL1825138 — — 2 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL49120 PD-0166285 Ki = 1.585 nM 8.80
CHEMBL1996702 — Ki = 3.162 nM 8.50
CHEMBL509032 TAE-684 Ki = 10.0 nM 8.00
CHEMBL550418 — Ki = 15.85 nM 7.80
CHEMBL1983923 — Ki = 31.62 nM 7.50
CHEMBL1983715 — Ki = 39.81 nM 7.40
CHEMBL1999484 — Ki = 39.81 nM 7.40
CHEMBL1967878 CENISERTIB Ki = 39.81 nM 7.40
CHEMBL1983575 — Ki = 39.81 nM 7.40
CHEMBL1976420 — Ki = 39.81 nM 7.40
CHEMBL101311 — Ki = 50.12 nM 7.30
CHEMBL1999414 — Ki = 50.12 nM 7.30
CHEMBL50894 ALSTERPAULLONE Ki = 63.1 nM 7.20
CHEMBL406845 — Ki = 63.1 nM 7.20
CHEMBL2001987 — Ki = 63.1 nM 7.20
CHEMBL1980995 — Ki = 63.1 nM 7.20
CHEMBL1081312 — Ki = 63.1 nM 7.20
CHEMBL5416410 DASATINIB Ki = 79.43 nM 7.10
CHEMBL1996649 — Ki = 100.0 nM 7.00
CHEMBL379975 — Ki = 100.0 nM 7.00
CHEMBL1972220 — Ki = 100.0 nM 7.00
CHEMBL1994555 — Ki = 100.0 nM 7.00
CHEMBL1979690 — Ki = 100.0 nM 7.00
CHEMBL1987998 — Ki = 125.89 nM 6.90
CHEMBL1981047 — Ki = 125.89 nM 6.90
CHEMBL1988581 — Ki = 125.89 nM 6.90
CHEMBL1981215 — Ki = 125.89 nM 6.90
CHEMBL1986756 — Ki = 125.89 nM 6.90
CHEMBL1967998 — Ki = 125.89 nM 6.90
CHEMBL1825138 — Ki = 158.49 nM 6.80
CHEMBL1993661 — Ki = 158.49 nM 6.80
CHEMBL1989471 — Ki = 158.49 nM 6.80
CHEMBL1997924 — Ki = 158.49 nM 6.80
CHEMBL2004290 — Ki = 199.53 nM 6.70
CHEMBL1968868 — Ki = 199.53 nM 6.70
CHEMBL1975903 — Ki = 199.53 nM 6.70
CHEMBL1970317 — Ki = 199.53 nM 6.70
CHEMBL1973359 — Ki = 199.53 nM 6.70
CHEMBL24828 VANDETANIB Ki = 199.53 nM 6.70
CHEMBL1980391 RG-1530 Ki = 251.19 nM 6.60
CHEMBL1989708 — Ki = 251.19 nM 6.60
CHEMBL1964444 — Ki = 316.23 nM 6.50
CHEMBL1949855 — Ki = 316.23 nM 6.50
CHEMBL1980297 ILORASERTIB Ki = 398.11 nM 6.40
CHEMBL1983111 — Ki = 398.11 nM 6.40
CHEMBL253969 OSI-632 Ki = 398.11 nM 6.40
CHEMBL1980671 — Ki = 501.19 nM 6.30
CHEMBL2006564 — Ki = 501.19 nM 6.30
CHEMBL1991734 — Ki = 501.19 nM 6.30
CHEMBL1972346 — Ki = 501.19 nM 6.30