Compound Detail
CHEMBL1986756
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Basic Information
| ChEMBL ID | CHEMBL1986756 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WRZNQKSBJJKEBD-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
360.3
MW (Da)
4.86
ALogP
3
HBA
2
HBD
66.9
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 7.5
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | Ki | 7.5 | 7.5 | 31.6 | 1 |
| Glycogen synthase kinase-3 alpha CHEMBL2850 | Ki | 7.3 | 7.3 | 50.1 | 1 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Ki | 7.2 | 7.2 | 63.1 | 1 |
| Activin receptor type-1 CHEMBL5903 | Ki | 6.9 | 6.9 | 125.9 | 1 |
| Tyrosine-protein kinase receptor TYRO3 CHEMBL5314 | Ki | 6.6 | 6.6 | 251.2 | 1 |
| Macrophage-stimulating protein receptor CHEMBL2689 | Ki | 6.4 | 6.4 | 398.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | Ki | = | 31.62 | nM | 7.5 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Glycogen synthase kinase-3 alpha | Ki | = | 50.12 | nM | 7.3 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Dual specificity protein kinase CLK4 | Ki | = | 63.1 | nM | 7.2 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Activin receptor type-1 | Ki | = | 125.89 | nM | 6.9 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Tyrosine-protein kinase receptor TYRO3 | Ki | = | 251.19 | nM | 6.6 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Macrophage-stimulating protein receptor | Ki | = | 398.11 | nM | 6.4 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
Data from ChEMBL 36 via Core Engine