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Assay Detail

CHEMBL1963697

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PLK3
ChEMBL ↗
734
Total Activities
721
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase PLK3 (CHEMBL4897) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 734 5.94 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1968380 — — 1 8.30
CHEMBL244378 — — 1 8.20
CHEMBL514499 GW843682X — 1 8.10
CHEMBL1241473 — — 1 7.90
CHEMBL2005375 — — 1 7.90
CHEMBL1964399 — — 1 7.90
CHEMBL1978448 — — 1 7.80
CHEMBL1969523 — — 1 7.80
CHEMBL396523 — — 1 7.60
CHEMBL474432 — — 1 7.50
CHEMBL2000335 — — 1 7.40
CHEMBL475251 R-406 2.0 1 7.30
CHEMBL1967560 — — 1 7.30
CHEMBL243088 — — 1 7.30
CHEMBL213505 — — 1 7.20
CHEMBL1998585 — — 1 7.20
CHEMBL2006715 — — 1 7.20
CHEMBL1970083 — — 1 7.10
CHEMBL539474 — — 1 7.10
CHEMBL1996831 — — 1 7.10
CHEMBL1988173 — — 1 7.00
CHEMBL2006263 — — 1 7.00
CHEMBL262433 — — 1 7.00
CHEMBL481491 — — 1 6.90
CHEMBL1999496 — — 1 6.80
CHEMBL211378 — — 1 6.70
CHEMBL1993661 — — 1 6.60
CHEMBL1986263 — — 1 6.60
CHEMBL2004544 — — 1 6.60
CHEMBL1983963 — — 1 6.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1968380 — Ki = 5.012 nM 8.30
CHEMBL244378 — Ki = 6.31 nM 8.20
CHEMBL514499 GW843682X Ki = 7.943 nM 8.10
CHEMBL1964399 — Ki = 12.59 nM 7.90
CHEMBL2005375 — Ki = 12.59 nM 7.90
CHEMBL1241473 — Ki = 12.59 nM 7.90
CHEMBL1969523 — Ki = 15.85 nM 7.80
CHEMBL1978448 — Ki = 15.85 nM 7.80
CHEMBL396523 — Ki = 25.12 nM 7.60
CHEMBL474432 — Ki = 31.62 nM 7.50
CHEMBL2000335 — Ki = 39.81 nM 7.40
CHEMBL475251 R-406 Ki = 50.12 nM 7.30
CHEMBL243088 — Ki = 50.12 nM 7.30
CHEMBL1967560 — Ki = 50.12 nM 7.30
CHEMBL213505 — Ki = 63.1 nM 7.20
CHEMBL2006715 — Ki = 63.1 nM 7.20
CHEMBL1998585 — Ki = 63.1 nM 7.20
CHEMBL1996831 — Ki = 79.43 nM 7.10
CHEMBL539474 — Ki = 79.43 nM 7.10
CHEMBL1970083 — Ki = 79.43 nM 7.10
CHEMBL1988173 — Ki = 100.0 nM 7.00
CHEMBL2006263 — Ki = 100.0 nM 7.00
CHEMBL262433 — Ki = 100.0 nM 7.00
CHEMBL481491 — Ki = 125.89 nM 6.90
CHEMBL1999496 — Ki = 158.49 nM 6.80
CHEMBL211378 — Ki = 199.53 nM 6.70
CHEMBL1983963 — Ki = 251.19 nM 6.60
CHEMBL1986263 — Ki = 251.19 nM 6.60
CHEMBL1993661 — Ki = 251.19 nM 6.60
CHEMBL2004544 — Ki = 251.19 nM 6.60
CHEMBL1967116 — Ki = 316.23 nM 6.50
CHEMBL1997349 — Ki = 316.23 nM 6.50
CHEMBL196363 — Ki = 316.23 nM 6.50
CHEMBL1971017 — Ki = 398.11 nM 6.40
CHEMBL271381 — Ki = 398.11 nM 6.40
CHEMBL1969537 — Ki = 398.11 nM 6.40
CHEMBL1974310 — Ki = 398.11 nM 6.40
CHEMBL1964687 — Ki = 501.19 nM 6.30
CHEMBL225519 — Ki = 501.19 nM 6.30
CHEMBL2006836 — Ki = 501.19 nM 6.30
CHEMBL1970317 — Ki = 501.19 nM 6.30
CHEMBL1987034 — Ki = 501.19 nM 6.30
CHEMBL2001751 — Ki = 501.19 nM 6.30
CHEMBL1969102 — Ki = 630.96 nM 6.20
CHEMBL1980896 — Ki = 630.96 nM 6.20
CHEMBL371206 — Ki = 630.96 nM 6.20
CHEMBL1974157 — Ki = 630.96 nM 6.20
CHEMBL1999126 — Ki = 630.96 nM 6.20
CHEMBL1989805 — Ki = 630.96 nM 6.20
CHEMBL1996979 — Ki = 630.96 nM 6.20