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Assay Detail

CHEMBL1963698

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: TBK1
ChEMBL ↗
323
Total Activities
316
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase TBK1 (CHEMBL5408) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 323 5.91 8.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 8.90
CHEMBL1980407 — — 1 8.10
CHEMBL1983111 — — 1 7.90
CHEMBL1991078 — — 1 7.60
CHEMBL1993661 — — 1 7.40
CHEMBL482967 CYC-116 1.0 1 7.20
CHEMBL1967878 CENISERTIB 2.0 1 7.10
CHEMBL1991725 — — 1 7.10
CHEMBL2006564 — — 1 7.10
CHEMBL475251 R-406 2.0 1 7.00
CHEMBL1983715 — — 1 7.00
CHEMBL1979690 — — 1 7.00
CHEMBL1988581 — — 1 6.90
CHEMBL1999484 — — 1 6.80
CHEMBL1983923 — — 1 6.80
CHEMBL1970104 — — 2 6.80
CHEMBL21156 — — 1 6.70
CHEMBL1992581 — — 1 6.70
CHEMBL1975927 — — 1 6.50
CHEMBL1991734 — — 1 6.50
CHEMBL1983348 — — 1 6.50
CHEMBL2000029 — — 1 6.50
CHEMBL1967998 — — 1 6.50
CHEMBL242865 — — 1 6.40
CHEMBL2004118 — — 1 6.30
CHEMBL1973359 — — 1 6.30
CHEMBL360847 — — 1 6.30
CHEMBL2006765 — — 1 6.30
CHEMBL509032 TAE-684 — 1 6.20
CHEMBL1972346 — — 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 1.259 nM 8.90
CHEMBL1980407 — Ki = 7.943 nM 8.10
CHEMBL1983111 — Ki = 12.59 nM 7.90
CHEMBL1991078 — Ki = 25.12 nM 7.60
CHEMBL1993661 — Ki = 39.81 nM 7.40
CHEMBL482967 CYC-116 Ki = 63.1 nM 7.20
CHEMBL1967878 CENISERTIB Ki = 79.43 nM 7.10
CHEMBL1991725 — Ki = 79.43 nM 7.10
CHEMBL2006564 — Ki = 79.43 nM 7.10
CHEMBL475251 R-406 Ki = 100.0 nM 7.00
CHEMBL1983715 — Ki = 100.0 nM 7.00
CHEMBL1979690 — Ki = 100.0 nM 7.00
CHEMBL1988581 — Ki = 125.89 nM 6.90
CHEMBL1970104 — Ki = 158.49 nM 6.80
CHEMBL1983923 — Ki = 158.49 nM 6.80
CHEMBL1970104 — Ki = 158.49 nM 6.80
CHEMBL1999484 — Ki = 158.49 nM 6.80
CHEMBL1992581 — Ki = 199.53 nM 6.70
CHEMBL21156 — Ki = 199.53 nM 6.70
CHEMBL1975927 — Ki = 316.23 nM 6.50
CHEMBL1967998 — Ki = 316.23 nM 6.50
CHEMBL1991734 — Ki = 316.23 nM 6.50
CHEMBL2000029 — Ki = 316.23 nM 6.50
CHEMBL1983348 — Ki = 316.23 nM 6.50
CHEMBL242865 — Ki = 398.11 nM 6.40
CHEMBL1973359 — Ki = 501.19 nM 6.30
CHEMBL2004118 — Ki = 501.19 nM 6.30
CHEMBL360847 — Ki = 501.19 nM 6.30
CHEMBL2006765 — Ki = 501.19 nM 6.30
CHEMBL509032 TAE-684 Ki = 630.96 nM 6.20
CHEMBL2000832 — Ki = 630.96 nM 6.20
CHEMBL1997335 — Ki = 630.96 nM 6.20
CHEMBL1972346 — Ki = 630.96 nM 6.20
CHEMBL1985681 — Ki = 794.33 nM 6.10
CHEMBL1982711 — Ki = 794.33 nM 6.10
CHEMBL1995811 — Ki = 794.33 nM 6.10
CHEMBL1983575 — Ki = 794.33 nM 6.10
CHEMBL1993335 — Ki = 1000.0 nM 6.00
CHEMBL1986943 — Ki = 1000.0 nM 6.00
CHEMBL1976040 ADAVOSERTIB Ki = 1000.0 nM 6.00
CHEMBL1986943 — Ki = 1000.0 nM 6.00
CHEMBL1974310 — Ki = 1258.93 nM 5.90
CHEMBL1989471 — Ki = 1258.93 nM 5.90
CHEMBL497151 — Ki = 1258.93 nM 5.90
CHEMBL1980329 — Ki = 1258.93 nM 5.90
CHEMBL458997 — Ki = 1258.93 nM 5.90
CHEMBL1975534 — Ki = 1258.93 nM 5.90
CHEMBL1972355 — Ki = 1584.89 nM 5.80
CHEMBL1988437 — Ki = 1584.89 nM 5.80
CHEMBL1978166 — Ki = 1584.89 nM 5.80