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Assay Detail

CHEMBL1963704

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ALK
ChEMBL ↗
764
Total Activities
746
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

ALK tyrosine kinase receptor (CHEMBL4247) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 764 6.06 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1983268 ENTRECTINIB 4.0 1 9.00
CHEMBL461876 — — 1 8.90
CHEMBL1971029 — — 1 8.80
CHEMBL1825138 — — 3 8.50
CHEMBL411903 — — 1 8.40
CHEMBL1993661 — — 1 8.40
CHEMBL1980995 — — 1 8.30
CHEMBL1967878 CENISERTIB 2.0 2 8.00
CHEMBL1998585 — — 1 7.90
CHEMBL1980329 — — 1 7.90
CHEMBL1971914 — — 1 7.80
CHEMBL271381 — — 1 7.80
CHEMBL1979516 — — 1 7.80
CHEMBL1979690 — — 1 7.60
CHEMBL1970083 — — 1 7.60
CHEMBL1981047 — — 1 7.60
CHEMBL1990228 — — 1 7.60
CHEMBL458997 — — 1 7.60
CHEMBL1974061 — — 1 7.40
CHEMBL1973961 — — 1 7.40
CHEMBL1973937 — — 1 7.30
CHEMBL1164180 — — 1 7.30
CHEMBL2000393 — — 1 7.30
CHEMBL1987034 — — 1 7.30
CHEMBL1968791 — — 1 7.20
CHEMBL1997924 — — 1 7.20
CHEMBL244793 — — 1 7.20
CHEMBL1974328 — — 1 7.20
CHEMBL1977138 — — 1 7.20
CHEMBL1989708 — — 1 7.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1983268 ENTRECTINIB Ki = 1.0 nM 9.00
CHEMBL461876 — Ki = 1.259 nM 8.90
CHEMBL1971029 — Ki = 1.585 nM 8.80
CHEMBL1825138 — Ki = 3.162 nM 8.50
CHEMBL411903 — Ki = 3.981 nM 8.40
CHEMBL1993661 — Ki = 3.981 nM 8.40
CHEMBL1980995 — Ki = 5.012 nM 8.30
CHEMBL1967878 CENISERTIB Ki = 10.0 nM 8.00
CHEMBL1825138 — Ki = 12.59 nM 7.90
CHEMBL1998585 — Ki = 12.59 nM 7.90
CHEMBL1980329 — Ki = 12.59 nM 7.90
CHEMBL271381 — Ki = 15.85 nM 7.80
CHEMBL1971914 — Ki = 15.85 nM 7.80
CHEMBL1979516 — Ki = 15.85 nM 7.80
CHEMBL1979690 — Ki = 25.12 nM 7.60
CHEMBL1970083 — Ki = 25.12 nM 7.60
CHEMBL458997 — Ki = 25.12 nM 7.60
CHEMBL1981047 — Ki = 25.12 nM 7.60
CHEMBL1990228 — Ki = 25.12 nM 7.60
CHEMBL1974061 — Ki = 39.81 nM 7.40
CHEMBL1973961 — Ki = 39.81 nM 7.40
CHEMBL1987034 — Ki = 50.12 nM 7.30
CHEMBL2000393 — Ki = 50.12 nM 7.30
CHEMBL1164180 — Ki = 50.12 nM 7.30
CHEMBL1973937 — Ki = 50.12 nM 7.30
CHEMBL1983634 — Ki = 63.1 nM 7.20
CHEMBL1989708 — Ki = 63.1 nM 7.20
CHEMBL1997924 — Ki = 63.1 nM 7.20
CHEMBL244793 — Ki = 63.1 nM 7.20
CHEMBL1974328 — Ki = 63.1 nM 7.20
CHEMBL1825138 — Ki = 63.1 nM 7.20
CHEMBL1968791 — Ki = 63.1 nM 7.20
CHEMBL1977138 — Ki = 63.1 nM 7.20
CHEMBL1972584 — Ki = 79.43 nM 7.10
CHEMBL1972584 — Ki = 79.43 nM 7.10
CHEMBL1993424 — Ki = 79.43 nM 7.10
CHEMBL1992527 — Ki = 79.43 nM 7.10
CHEMBL1967998 — Ki = 100.0 nM 7.00
CHEMBL1967878 CENISERTIB Ki = 100.0 nM 7.00
CHEMBL1988581 — Ki = 100.0 nM 7.00
CHEMBL1241473 — Ki = 100.0 nM 7.00
CHEMBL1164265 — Ki = 100.0 nM 7.00
CHEMBL1979883 — Ki = 100.0 nM 7.00
CHEMBL1983111 — Ki = 100.0 nM 7.00
CHEMBL2005714 — Ki = 125.89 nM 6.90
CHEMBL1973516 — Ki = 125.89 nM 6.90
CHEMBL1971021 — Ki = 125.89 nM 6.90
CHEMBL2007421 — Ki = 125.89 nM 6.90
CHEMBL1994669 — Ki = 125.89 nM 6.90
CHEMBL2006564 — Ki = 125.89 nM 6.90