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Assay Detail

CHEMBL1963722

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2
ChEMBL ↗
848
Total Activities
836
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Rho-associated protein kinase 2 (CHEMBL2973) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 848 6.67 9.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 9.30
CHEMBL1870106 — — 1 9.20
CHEMBL1973720 — — 2 8.70
CHEMBL1975418 — — 1 8.60
CHEMBL1969151 — — 1 8.60
CHEMBL1974288 — — 1 8.60
CHEMBL1983589 — — 1 8.50
CHEMBL340384 — — 1 8.50
CHEMBL1979554 — — 1 8.50
CHEMBL1990254 — — 1 8.50
CHEMBL1998121 — — 1 8.40
CHEMBL1968930 — — 1 8.40
CHEMBL1983534 — — 1 8.40
CHEMBL2002346 — — 1 8.40
CHEMBL1983945 — — 1 8.40
CHEMBL1976240 — — 1 8.30
CHEMBL1967544 — — 1 8.30
CHEMBL1964340 — — 1 8.30
CHEMBL1999428 — — 1 8.20
CHEMBL213207 — — 1 8.20
CHEMBL1082440 — — 1 8.10
CHEMBL1987448 — — 1 8.10
CHEMBL1970903 — — 1 8.10
CHEMBL1982271 — — 1 8.10
CHEMBL1998068 — — 1 8.10
CHEMBL1996980 — — 1 8.10
CHEMBL2000271 — — 1 8.10
CHEMBL1969588 — — 1 8.00
CHEMBL1968245 — — 1 8.00
CHEMBL1966524 — — 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 0.5012 nM 9.30
CHEMBL1870106 — Ki = 0.631 nM 9.20
CHEMBL1973720 — Ki = 1.995 nM 8.70
CHEMBL1973720 — Ki = 1.995 nM 8.70
CHEMBL1969151 — Ki = 2.512 nM 8.60
CHEMBL1975418 — Ki = 2.512 nM 8.60
CHEMBL1974288 — Ki = 2.512 nM 8.60
CHEMBL1979554 — Ki = 3.162 nM 8.50
CHEMBL340384 — Ki = 3.162 nM 8.50
CHEMBL1983589 — Ki = 3.162 nM 8.50
CHEMBL1990254 — Ki = 3.162 nM 8.50
CHEMBL1968930 — Ki = 3.981 nM 8.40
CHEMBL1983945 — Ki = 3.981 nM 8.40
CHEMBL2002346 — Ki = 3.981 nM 8.40
CHEMBL1983534 — Ki = 3.981 nM 8.40
CHEMBL1998121 — Ki = 3.981 nM 8.40
CHEMBL1967544 — Ki = 5.012 nM 8.30
CHEMBL1964340 — Ki = 5.012 nM 8.30
CHEMBL1976240 — Ki = 5.012 nM 8.30
CHEMBL1999428 — Ki = 6.31 nM 8.20
CHEMBL213207 — Ki = 6.31 nM 8.20
CHEMBL1996980 — Ki = 7.943 nM 8.10
CHEMBL1982271 — Ki = 7.943 nM 8.10
CHEMBL1082440 — Ki = 7.943 nM 8.10
CHEMBL1987448 — Ki = 7.943 nM 8.10
CHEMBL2000271 — Ki = 7.943 nM 8.10
CHEMBL1970903 — Ki = 7.943 nM 8.10
CHEMBL1998068 — Ki = 7.943 nM 8.10
CHEMBL2000894 — Ki = 10.0 nM 8.00
CHEMBL1966524 — Ki = 10.0 nM 8.00
CHEMBL1968245 — Ki = 10.0 nM 8.00
CHEMBL1967662 — Ki = 10.0 nM 8.00
CHEMBL1994438 — Ki = 10.0 nM 8.00
CHEMBL1969588 — Ki = 10.0 nM 8.00
CHEMBL1992073 — Ki = 12.59 nM 7.90
CHEMBL1995932 — Ki = 12.59 nM 7.90
CHEMBL1991674 — Ki = 12.59 nM 7.90
CHEMBL1972158 — Ki = 12.59 nM 7.90
CHEMBL2001751 — Ki = 12.59 nM 7.90
CHEMBL1996339 — Ki = 12.59 nM 7.90
CHEMBL1966279 — Ki = 15.85 nM 7.80
CHEMBL1972290 — Ki = 15.85 nM 7.80
CHEMBL1970821 — Ki = 15.85 nM 7.80
CHEMBL1974935 — Ki = 15.85 nM 7.80
CHEMBL1986499 — Ki = 15.85 nM 7.80
CHEMBL2006456 — Ki = 15.85 nM 7.80
CHEMBL2005387 — Ki = 15.85 nM 7.80
CHEMBL2000481 — Ki = 15.85 nM 7.80
CHEMBL1994669 — Ki = 15.85 nM 7.80
CHEMBL340921 — Ki = 15.85 nM 7.80