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Assay Detail

CHEMBL1963728

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPKAPK5
ChEMBL ↗
521
Total Activities
514
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

MAP kinase-activated protein kinase 5 (CHEMBL3094) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 521 6.31 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1978448 — — 1 8.00
CHEMBL1997129 — — 1 7.20
CHEMBL226403 — — 1 7.20
CHEMBL514499 GW843682X — 1 7.20
CHEMBL1975138 — — 1 7.10
CHEMBL539474 — — 1 6.90
CHEMBL592030 — — 1 6.70
CHEMBL1966722 — — 1 6.60
CHEMBL226471 — — 1 6.60
CHEMBL1986328 — — 1 6.60
CHEMBL1989805 — — 1 6.50
CHEMBL1973540 — — 1 6.40
CHEMBL1988173 — — 1 6.40
CHEMBL2000832 — — 1 6.40
CHEMBL2006263 — — 1 6.40
CHEMBL2004544 — — 1 6.40
CHEMBL1997349 — — 1 6.30
CHEMBL1985095 — — 1 6.20
CHEMBL2006156 — — 1 6.20
CHEMBL1987793 — — 1 6.20
CHEMBL2004365 — — 1 6.20
CHEMBL1975233 — — 1 6.20
CHEMBL1991429 — — 1 6.20
CHEMBL1986943 — — 2 6.10
CHEMBL1986263 — — 1 6.10
CHEMBL1983195 — — 1 6.10
CHEMBL2006715 — — 1 6.10
CHEMBL583144 — — 1 6.00
CHEMBL2000335 — — 1 6.00
CHEMBL1980142 — — 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1978448 — Ki = 10.0 nM 8.00
CHEMBL226403 — Ki = 63.1 nM 7.20
CHEMBL514499 GW843682X Ki = 63.1 nM 7.20
CHEMBL1997129 — Ki = 63.1 nM 7.20
CHEMBL1975138 — Ki = 79.43 nM 7.10
CHEMBL539474 — Ki = 125.89 nM 6.90
CHEMBL592030 — Ki = 199.53 nM 6.70
CHEMBL1966722 — Ki = 251.19 nM 6.60
CHEMBL226471 — Ki = 251.19 nM 6.60
CHEMBL1986328 — Ki = 251.19 nM 6.60
CHEMBL1989805 — Ki = 316.23 nM 6.50
CHEMBL1973540 — Ki = 398.11 nM 6.40
CHEMBL2006263 — Ki = 398.11 nM 6.40
CHEMBL2004544 — Ki = 398.11 nM 6.40
CHEMBL2000832 — Ki = 398.11 nM 6.40
CHEMBL1988173 — Ki = 398.11 nM 6.40
CHEMBL1997349 — Ki = 501.19 nM 6.30
CHEMBL2006156 — Ki = 630.96 nM 6.20
CHEMBL1975233 — Ki = 630.96 nM 6.20
CHEMBL1987793 — Ki = 630.96 nM 6.20
CHEMBL1985095 — Ki = 630.96 nM 6.20
CHEMBL2004365 — Ki = 630.96 nM 6.20
CHEMBL1991429 — Ki = 630.96 nM 6.20
CHEMBL1983195 — Ki = 794.33 nM 6.10
CHEMBL2006715 — Ki = 794.33 nM 6.10
CHEMBL1986263 — Ki = 794.33 nM 6.10
CHEMBL1986943 — Ki = 794.33 nM 6.10
CHEMBL1986943 — Ki = 794.33 nM 6.10
CHEMBL583144 — Ki = 1000.0 nM 6.00
CHEMBL2000335 — Ki = 1000.0 nM 6.00
CHEMBL1980142 — Ki = 1000.0 nM 6.00
CHEMBL1999112 — Ki = 1258.93 nM 5.90
CHEMBL1973937 — Ki = 1258.93 nM 5.90
CHEMBL1991078 — Ki = 1258.93 nM 5.90
CHEMBL262433 — Ki = 1258.93 nM 5.90
CHEMBL1970203 — Ki = 1258.93 nM 5.90
CHEMBL1984274 — Ki = 1258.93 nM 5.90
CHEMBL1990432 — Ki = 1258.93 nM 5.90
CHEMBL1996831 — Ki = 1584.89 nM 5.80
CHEMBL1969537 — Ki = 1584.89 nM 5.80
CHEMBL1985406 — Ki = 1584.89 nM 5.80
CHEMBL1972576 — Ki = 1584.89 nM 5.80
CHEMBL1516890 GW441756X Ki > 1584.89 nM -
CHEMBL1979057 — Ki > 1584.89 nM -
CHEMBL1970217 — Ki > 1584.89 nM -
CHEMBL1999428 — Ki > 1584.89 nM -
CHEMBL387971 — Ki > 1584.89 nM -
CHEMBL1230122 R-1487 Ki > 1584.89 nM -
CHEMBL211378 — Ki > 1584.89 nM -
CHEMBL1967560 — Ki > 1584.89 nM -