Compound Detail
CHEMBL1990432
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Basic Information
| ChEMBL ID | CHEMBL1990432 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MSHWFKSJTARSSX-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
358.2
MW (Da)
4.75
ALogP
2
HBA
1
HBD
49.9
PSA (Ų)
0.68
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 5.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-activated protein kinase 5 CHEMBL3094 | Ki | 5.9 | 5.9 | 1258.9 | 1 |
| Tyrosine-protein kinase receptor UFO CHEMBL4895 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Protein-tyrosine kinase 2-beta CHEMBL5469 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 5.3 | 5.3 | 5011.9 | 1 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Ki | 5.2 | 5.2 | 6309.6 | 1 |
| SRSF protein kinase 1 CHEMBL4375 | Ki | 5.2 | 5.2 | 6309.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-activated protein kinase 5 | Ki | = | 1258.93 | nM | 5.9 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Tyrosine-protein kinase receptor UFO | Ki | = | 1584.89 | nM | 5.8 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Protein-tyrosine kinase 2-beta | Ki | = | 1584.89 | nM | 5.8 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Serine/threonine-protein kinase pim-1 | Ki | = | 5011.87 | nM | 5.3 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| SRSF protein kinase 1 | Ki | = | 6309.57 | nM | 5.2 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Dual specificity protein kinase CLK4 | Ki | = | 6309.57 | nM | 5.2 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
Data from ChEMBL 36 via Core Engine