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Assay Detail

CHEMBL1963760

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PTK2B
ChEMBL ↗
423
Total Activities
418
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Protein-tyrosine kinase 2-beta (CHEMBL5469) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 423 6.50 8.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1971029 — — 1 8.80
CHEMBL1084546 PF-00562271 1.0 1 8.50
CHEMBL1241473 — — 1 8.10
CHEMBL1987034 — — 1 8.00
CHEMBL411903 — — 1 7.70
CHEMBL2005886 — — 1 7.60
CHEMBL1984711 — — 1 7.40
CHEMBL1988387 — — 1 7.20
CHEMBL1967878 CENISERTIB 2.0 1 7.10
CHEMBL1988838 — — 1 7.00
CHEMBL2000393 — — 1 7.00
CHEMBL1998585 — — 1 6.90
CHEMBL1990885 — — 1 6.90
CHEMBL514499 GW843682X — 1 6.80
CHEMBL1825138 — — 1 6.80
CHEMBL1989708 — — 2 6.80
CHEMBL1978099 — — 1 6.70
CHEMBL271381 — — 1 6.70
CHEMBL1973540 — — 1 6.60
CHEMBL1967116 — — 1 6.60
CHEMBL592030 — — 1 6.60
CHEMBL2002702 — — 1 6.50
CHEMBL1970104 — — 2 6.50
CHEMBL2004716 — — 1 6.40
CHEMBL1984162 — — 1 6.40
CHEMBL2002165 — — 1 6.30
CHEMBL1974870 — — 1 6.30
CHEMBL474432 — — 1 6.30
CHEMBL1996817 — — 1 6.30
CHEMBL1982957 — — 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1971029 — Ki = 1.585 nM 8.80
CHEMBL1084546 PF-00562271 Ki = 3.162 nM 8.50
CHEMBL1241473 — Ki = 7.943 nM 8.10
CHEMBL1987034 — Ki = 10.0 nM 8.00
CHEMBL411903 — Ki = 19.95 nM 7.70
CHEMBL2005886 — Ki = 25.12 nM 7.60
CHEMBL1984711 — Ki = 39.81 nM 7.40
CHEMBL1988387 — Ki = 63.1 nM 7.20
CHEMBL1967878 CENISERTIB Ki = 79.43 nM 7.10
CHEMBL1988838 — Ki = 100.0 nM 7.00
CHEMBL2000393 — Ki = 100.0 nM 7.00
CHEMBL1998585 — Ki = 125.89 nM 6.90
CHEMBL1990885 — Ki = 125.89 nM 6.90
CHEMBL1989708 — Ki = 158.49 nM 6.80
CHEMBL514499 GW843682X Ki = 158.49 nM 6.80
CHEMBL1825138 — Ki = 158.49 nM 6.80
CHEMBL1978099 — Ki = 199.53 nM 6.70
CHEMBL271381 — Ki = 199.53 nM 6.70
CHEMBL1967116 — Ki = 251.19 nM 6.60
CHEMBL1973540 — Ki = 251.19 nM 6.60
CHEMBL592030 — Ki = 251.19 nM 6.60
CHEMBL2002702 — Ki = 316.23 nM 6.50
CHEMBL1970104 — Ki = 316.23 nM 6.50
CHEMBL1970104 — Ki = 316.23 nM 6.50
CHEMBL2004716 — Ki = 398.11 nM 6.40
CHEMBL1984162 — Ki = 398.11 nM 6.40
CHEMBL1989708 — Ki = 398.11 nM 6.40
CHEMBL1982957 — Ki = 501.19 nM 6.30
CHEMBL1974870 — Ki = 501.19 nM 6.30
CHEMBL474432 — Ki = 501.19 nM 6.30
CHEMBL2002165 — Ki = 501.19 nM 6.30
CHEMBL1996817 — Ki = 501.19 nM 6.30
CHEMBL1967720 — Ki = 501.19 nM 6.30
CHEMBL1997129 — Ki = 630.96 nM 6.20
CHEMBL1968380 — Ki = 630.96 nM 6.20
CHEMBL1992922 — Ki = 630.96 nM 6.20
CHEMBL1969190 — Ki = 794.33 nM 6.10
CHEMBL2000071 — Ki = 794.33 nM 6.10
CHEMBL1991063 — Ki = 794.33 nM 6.10
CHEMBL1965836 — Ki = 794.33 nM 6.10
CHEMBL2002726 — Ki = 1000.0 nM 6.00
CHEMBL1974254 — Ki = 1000.0 nM 6.00
CHEMBL340921 — Ki = 1000.0 nM 6.00
CHEMBL1994321 — Ki = 1000.0 nM 6.00
CHEMBL1985095 — Ki = 1000.0 nM 6.00
CHEMBL1987793 — Ki = 1000.0 nM 6.00
CHEMBL1988173 — Ki = 1000.0 nM 6.00
CHEMBL491758 — Ki = 1000.0 nM 6.00
CHEMBL1980297 ILORASERTIB Ki = 1258.93 nM 5.90
CHEMBL2006836 — Ki = 1258.93 nM 5.90