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Assay Detail

CHEMBL1963729

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAPKAPK2
ChEMBL ↗
753
Total Activities
742
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

MAP kinase-activated protein kinase 2 (CHEMBL2208) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 753 5.69 8.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL592030 — — 1 8.50
CHEMBL1241473 — — 1 8.20
CHEMBL1985095 — — 1 7.60
CHEMBL226403 — — 1 7.50
CHEMBL1980995 — — 1 7.10
CHEMBL1978448 — — 1 7.10
CHEMBL2000685 — — 1 6.70
CHEMBL1999931 — — 1 6.60
CHEMBL590109 — — 1 6.60
CHEMBL539474 — — 1 6.60
CHEMBL2003638 — — 1 6.50
CHEMBL413779 — — 1 6.30
CHEMBL1974870 — — 1 6.20
CHEMBL1991728 — — 1 6.20
CHEMBL2006010 — — 1 6.10
CHEMBL373598 — — 1 6.10
CHEMBL1989805 — — 1 6.10
CHEMBL1990254 — — 2 6.10
CHEMBL225519 — — 1 6.10
CHEMBL1964399 — — 1 6.10
CHEMBL1966628 — — 1 6.10
CHEMBL2006263 — — 1 6.00
CHEMBL1997129 — — 1 5.90
CHEMBL1984274 — — 1 5.90
CHEMBL1966722 — — 1 5.90
CHEMBL1989646 — — 1 5.90
CHEMBL1973540 — — 1 5.90
CHEMBL1991674 — — 1 5.90
CHEMBL1997349 — — 1 5.90
CHEMBL1973395 — — 1 5.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL592030 — Ki = 3.162 nM 8.50
CHEMBL1241473 — Ki = 6.31 nM 8.20
CHEMBL1985095 — Ki = 25.12 nM 7.60
CHEMBL226403 — Ki = 31.62 nM 7.50
CHEMBL1978448 — Ki = 79.43 nM 7.10
CHEMBL1980995 — Ki = 79.43 nM 7.10
CHEMBL2000685 — Ki = 199.53 nM 6.70
CHEMBL1999931 — Ki = 251.19 nM 6.60
CHEMBL590109 — Ki = 251.19 nM 6.60
CHEMBL539474 — Ki = 251.19 nM 6.60
CHEMBL2003638 — Ki = 316.23 nM 6.50
CHEMBL413779 — Ki = 501.19 nM 6.30
CHEMBL1974870 — Ki = 630.96 nM 6.20
CHEMBL1991728 — Ki = 630.96 nM 6.20
CHEMBL1990254 — Ki = 794.33 nM 6.10
CHEMBL2006010 — Ki = 794.33 nM 6.10
CHEMBL1966628 — Ki = 794.33 nM 6.10
CHEMBL1989805 — Ki = 794.33 nM 6.10
CHEMBL225519 — Ki = 794.33 nM 6.10
CHEMBL1964399 — Ki = 794.33 nM 6.10
CHEMBL373598 — Ki = 794.33 nM 6.10
CHEMBL2006263 — Ki = 1000.0 nM 6.00
CHEMBL1966722 — Ki = 1258.93 nM 5.90
CHEMBL1973540 — Ki = 1258.93 nM 5.90
CHEMBL1973395 — Ki = 1258.93 nM 5.90
CHEMBL1997129 — Ki = 1258.93 nM 5.90
CHEMBL1989646 — Ki = 1258.93 nM 5.90
CHEMBL1997349 — Ki = 1258.93 nM 5.90
CHEMBL1984274 — Ki = 1258.93 nM 5.90
CHEMBL2002726 — Ki = 1258.93 nM 5.90
CHEMBL1991674 — Ki = 1258.93 nM 5.90
CHEMBL1988173 — Ki = 1584.89 nM 5.80
CHEMBL1975128 — Ki = 1584.89 nM 5.80
CHEMBL2000832 — Ki = 1584.89 nM 5.80
CHEMBL1998159 — Ki = 1584.89 nM 5.80
CHEMBL1975418 — Ki = 1584.89 nM 5.80
CHEMBL223367 — Ki = 1584.89 nM 5.80
CHEMBL2004365 — Ki = 1584.89 nM 5.80
CHEMBL1993166 — Ki = 1584.89 nM 5.80
CHEMBL1969523 — Ki = 1584.89 nM 5.80
CHEMBL1991640 — Ki = 1995.26 nM 5.70
CHEMBL474432 — Ki = 1995.26 nM 5.70
CHEMBL1966425 — Ki = 1995.26 nM 5.70
CHEMBL1991078 — Ki = 1995.26 nM 5.70
CHEMBL1983195 — Ki = 1995.26 nM 5.70
CHEMBL2001751 — Ki = 1995.26 nM 5.70
CHEMBL1982711 — Ki = 1995.26 nM 5.70
CHEMBL2004544 — Ki = 1995.26 nM 5.70
CHEMBL1969537 — Ki = 1995.26 nM 5.70
CHEMBL1992922 — Ki = 1995.26 nM 5.70