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Assay Detail

CHEMBL1963733

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: BTK
ChEMBL ↗
726
Total Activities
707
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase BTK (CHEMBL5251) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 726 6.18 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1997617 — — 1 9.10
CHEMBL2001584 — — 1 8.50
CHEMBL49120 PD-0166285 1.0 1 8.00
CHEMBL1994938 — — 1 8.00
CHEMBL1988387 — — 1 7.90
CHEMBL1989267 — — 1 7.90
CHEMBL2002165 — — 1 7.70
CHEMBL1989708 — — 2 7.70
CHEMBL1973138 — — 1 7.70
CHEMBL1993941 — — 1 7.60
CHEMBL1967878 CENISERTIB 2.0 1 7.60
CHEMBL1980297 ILORASERTIB 2.0 1 7.60
CHEMBL1972584 — — 2 7.50
CHEMBL508928 — — 1 7.50
CHEMBL1967720 — — 1 7.40
CHEMBL1984162 — — 1 7.40
CHEMBL509032 TAE-684 — 1 7.30
CHEMBL306380 — — 1 7.20
CHEMBL1972220 — — 1 7.20
CHEMBL1979516 — — 1 7.20
CHEMBL1974254 — — 1 7.10
CHEMBL1980995 — — 1 7.10
CHEMBL1973540 — — 1 7.10
CHEMBL1976376 — — 1 7.10
CHEMBL2005886 — — 1 7.00
CHEMBL1981725 — — 1 7.00
CHEMBL1965170 — — 1 7.00
CHEMBL1996979 — — 1 6.90
CHEMBL1978166 — — 2 6.90
CHEMBL1993243 — — 1 6.90

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1997617 — Ki = 0.7943 nM 9.10
CHEMBL2001584 — Ki = 3.162 nM 8.50
CHEMBL1994938 — Ki = 10.0 nM 8.00
CHEMBL49120 PD-0166285 Ki = 10.0 nM 8.00
CHEMBL1988387 — Ki = 12.59 nM 7.90
CHEMBL1989267 — Ki = 12.59 nM 7.90
CHEMBL2002165 — Ki = 19.95 nM 7.70
CHEMBL1989708 — Ki = 19.95 nM 7.70
CHEMBL1973138 — Ki = 19.95 nM 7.70
CHEMBL1980297 ILORASERTIB Ki = 25.12 nM 7.60
CHEMBL1993941 — Ki = 25.12 nM 7.60
CHEMBL1967878 CENISERTIB Ki = 25.12 nM 7.60
CHEMBL1989708 — Ki = 31.62 nM 7.50
CHEMBL508928 — Ki = 31.62 nM 7.50
CHEMBL1972584 — Ki = 31.62 nM 7.50
CHEMBL1972584 — Ki = 31.62 nM 7.50
CHEMBL1967720 — Ki = 39.81 nM 7.40
CHEMBL1984162 — Ki = 39.81 nM 7.40
CHEMBL509032 TAE-684 Ki = 50.12 nM 7.30
CHEMBL1979516 — Ki = 63.1 nM 7.20
CHEMBL1972220 — Ki = 63.1 nM 7.20
CHEMBL306380 — Ki = 63.1 nM 7.20
CHEMBL1980995 — Ki = 79.43 nM 7.10
CHEMBL1973540 — Ki = 79.43 nM 7.10
CHEMBL1976376 — Ki = 79.43 nM 7.10
CHEMBL1974254 — Ki = 79.43 nM 7.10
CHEMBL2005886 — Ki = 100.0 nM 7.00
CHEMBL1965170 — Ki = 100.0 nM 7.00
CHEMBL1981725 — Ki = 100.0 nM 7.00
CHEMBL1993661 — Ki = 125.89 nM 6.90
CHEMBL1996979 — Ki = 125.89 nM 6.90
CHEMBL1978166 — Ki = 125.89 nM 6.90
CHEMBL1993243 — Ki = 125.89 nM 6.90
CHEMBL1978166 — Ki = 125.89 nM 6.90
CHEMBL1998112 — Ki = 158.49 nM 6.80
CHEMBL2006564 — Ki = 158.49 nM 6.80
CHEMBL1988581 — Ki = 158.49 nM 6.80
CHEMBL1983268 ENTRECTINIB Ki = 158.49 nM 6.80
CHEMBL1988838 — Ki = 158.49 nM 6.80
CHEMBL1987034 — Ki = 158.49 nM 6.80
CHEMBL2001485 — Ki = 158.49 nM 6.80
CHEMBL1980391 RG-1530 Ki = 199.53 nM 6.70
CHEMBL1981047 — Ki = 199.53 nM 6.70
CHEMBL1977148 — Ki = 251.19 nM 6.60
CHEMBL243088 — Ki = 251.19 nM 6.60
CHEMBL2004290 — Ki = 251.19 nM 6.60
CHEMBL491758 — Ki = 251.19 nM 6.60
CHEMBL1974416 — Ki = 251.19 nM 6.60
CHEMBL1974664 — Ki = 316.23 nM 6.50
CHEMBL1969502 — Ki = 316.23 nM 6.50