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Assay Detail

CHEMBL1963744

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: RPS6KA5
ChEMBL ↗
451
Total Activities
447
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Ribosomal protein S6 kinase alpha-5 (CHEMBL4237) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 451 6.55 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1970903 — — 1 9.10
CHEMBL1991063 — — 1 8.90
CHEMBL1974870 — — 1 8.30
CHEMBL1979883 — — 1 8.30
CHEMBL1990254 — — 2 8.10
CHEMBL1969588 — — 1 7.80
CHEMBL1975900 — — 1 7.80
CHEMBL1975128 — — 1 7.70
CHEMBL1975121 — — 1 7.70
CHEMBL2001751 — — 1 7.60
CHEMBL1976240 — — 1 7.60
CHEMBL2001257 — — 1 7.50
CHEMBL1973211 — — 1 7.50
CHEMBL1967302 — — 1 7.50
CHEMBL1993722 — — 1 7.40
CHEMBL1979577 — — 1 7.40
CHEMBL1970709 — — 1 7.30
CHEMBL1965988 — — 1 7.30
CHEMBL1965836 — — 1 7.30
CHEMBL220241 GSK-269962A — 1 7.20
CHEMBL2000335 — — 1 7.10
CHEMBL2005936 — — 1 7.10
CHEMBL1983025 — — 1 7.10
CHEMBL1998159 — — 1 7.10
CHEMBL272453 — — 1 7.10
CHEMBL1993548 — — 1 7.10
CHEMBL1984162 — — 1 7.10
CHEMBL1987034 — — 1 7.00
CHEMBL1986970 — — 1 7.00
CHEMBL1999428 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1970903 — Ki = 0.7943 nM 9.10
CHEMBL1991063 — Ki = 1.259 nM 8.90
CHEMBL1979883 — Ki = 5.012 nM 8.30
CHEMBL1974870 — Ki = 5.012 nM 8.30
CHEMBL1990254 — Ki = 7.943 nM 8.10
CHEMBL1990254 — Ki = 7.943 nM 8.10
CHEMBL1975900 — Ki = 15.85 nM 7.80
CHEMBL1969588 — Ki = 15.85 nM 7.80
CHEMBL1975128 — Ki = 19.95 nM 7.70
CHEMBL1975121 — Ki = 19.95 nM 7.70
CHEMBL2001751 — Ki = 25.12 nM 7.60
CHEMBL1976240 — Ki = 25.12 nM 7.60
CHEMBL1973211 — Ki = 31.62 nM 7.50
CHEMBL2001257 — Ki = 31.62 nM 7.50
CHEMBL1967302 — Ki = 31.62 nM 7.50
CHEMBL1979577 — Ki = 39.81 nM 7.40
CHEMBL1993722 — Ki = 39.81 nM 7.40
CHEMBL1970709 — Ki = 50.12 nM 7.30
CHEMBL1965836 — Ki = 50.12 nM 7.30
CHEMBL1965988 — Ki = 50.12 nM 7.30
CHEMBL220241 GSK-269962A Ki = 63.1 nM 7.20
CHEMBL1993548 — Ki = 79.43 nM 7.10
CHEMBL2000335 — Ki = 79.43 nM 7.10
CHEMBL2005936 — Ki = 79.43 nM 7.10
CHEMBL1984162 — Ki = 79.43 nM 7.10
CHEMBL1998159 — Ki = 79.43 nM 7.10
CHEMBL272453 — Ki = 79.43 nM 7.10
CHEMBL1983025 — Ki = 79.43 nM 7.10
CHEMBL1986970 — Ki = 100.0 nM 7.00
CHEMBL1987034 — Ki = 100.0 nM 7.00
CHEMBL2002726 — Ki = 100.0 nM 7.00
CHEMBL1999428 — Ki = 100.0 nM 7.00
CHEMBL1994321 — Ki = 125.89 nM 6.90
CHEMBL1988173 — Ki = 125.89 nM 6.90
CHEMBL1998121 — Ki = 125.89 nM 6.90
CHEMBL1974288 — Ki = 125.89 nM 6.90
CHEMBL2003341 — Ki = 158.49 nM 6.80
CHEMBL1989646 — Ki = 158.49 nM 6.80
CHEMBL1969561 — Ki = 158.49 nM 6.80
CHEMBL1974935 — Ki = 158.49 nM 6.80
CHEMBL1984363 — Ki = 199.53 nM 6.70
CHEMBL2005631 — Ki = 199.53 nM 6.70
CHEMBL340384 — Ki = 199.53 nM 6.70
CHEMBL1988537 — Ki = 199.53 nM 6.70
CHEMBL1982465 — Ki = 199.53 nM 6.70
CHEMBL1970217 — Ki = 199.53 nM 6.70
CHEMBL1967116 — Ki = 251.19 nM 6.60
CHEMBL1964937 — Ki = 251.19 nM 6.60
CHEMBL1973937 — Ki = 251.19 nM 6.60
CHEMBL2000832 — Ki = 251.19 nM 6.60