Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1963770

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SRMS
ChEMBL ↗
470
Total Activities
464
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase Srms (CHEMBL5703) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 470 6.51 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5416410 DASATINIB 4.0 1 9.20
CHEMBL1997617 — — 1 8.20
CHEMBL2006715 — — 1 7.60
CHEMBL2004716 — — 1 7.60
CHEMBL1980297 ILORASERTIB 2.0 1 7.60
CHEMBL1988387 — — 1 7.30
CHEMBL1981047 — — 1 7.30
CHEMBL508928 — — 1 7.10
CHEMBL1993661 — — 1 7.00
CHEMBL1989708 — — 2 6.90
CHEMBL1996979 — — 1 6.90
CHEMBL1972584 — — 1 6.90
CHEMBL2005886 — — 1 6.80
CHEMBL1994938 — — 1 6.80
CHEMBL1968590 — — 1 6.70
CHEMBL1967720 — — 1 6.70
CHEMBL1990821 — — 1 6.70
CHEMBL1981725 — — 1 6.70
CHEMBL1987034 — — 1 6.60
CHEMBL2002165 — — 1 6.60
CHEMBL509032 TAE-684 — 1 6.50
CHEMBL1993941 — — 1 6.50
CHEMBL1982924 — — 1 6.40
CHEMBL2004311 — — 1 6.40
CHEMBL1993243 — — 1 6.30
CHEMBL306380 — — 1 6.30
CHEMBL1978448 — — 1 6.20
CHEMBL1987793 — — 1 6.20
CHEMBL1991429 — — 1 6.20
CHEMBL1984162 — — 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5416410 DASATINIB Ki = 0.631 nM 9.20
CHEMBL1997617 — Ki = 6.31 nM 8.20
CHEMBL2006715 — Ki = 25.12 nM 7.60
CHEMBL2004716 — Ki = 25.12 nM 7.60
CHEMBL1980297 ILORASERTIB Ki = 25.12 nM 7.60
CHEMBL1981047 — Ki = 50.12 nM 7.30
CHEMBL1988387 — Ki = 50.12 nM 7.30
CHEMBL508928 — Ki = 79.43 nM 7.10
CHEMBL1993661 — Ki = 100.0 nM 7.00
CHEMBL1989708 — Ki = 125.89 nM 6.90
CHEMBL1996979 — Ki = 125.89 nM 6.90
CHEMBL1972584 — Ki = 125.89 nM 6.90
CHEMBL1994938 — Ki = 158.49 nM 6.80
CHEMBL2005886 — Ki = 158.49 nM 6.80
CHEMBL1968590 — Ki = 199.53 nM 6.70
CHEMBL1990821 — Ki = 199.53 nM 6.70
CHEMBL1981725 — Ki = 199.53 nM 6.70
CHEMBL1967720 — Ki = 199.53 nM 6.70
CHEMBL2002165 — Ki = 251.19 nM 6.60
CHEMBL1987034 — Ki = 251.19 nM 6.60
CHEMBL509032 TAE-684 Ki = 316.23 nM 6.50
CHEMBL1993941 — Ki = 316.23 nM 6.50
CHEMBL1982924 — Ki = 398.11 nM 6.40
CHEMBL2004311 — Ki = 398.11 nM 6.40
CHEMBL1993243 — Ki = 501.19 nM 6.30
CHEMBL306380 — Ki = 501.19 nM 6.30
CHEMBL1991429 — Ki = 630.96 nM 6.20
CHEMBL1987793 — Ki = 630.96 nM 6.20
CHEMBL1984162 — Ki = 630.96 nM 6.20
CHEMBL1978448 — Ki = 630.96 nM 6.20
CHEMBL1989708 — Ki = 630.96 nM 6.20
CHEMBL458997 — Ki = 794.33 nM 6.10
CHEMBL1986943 — Ki = 794.33 nM 6.10
CHEMBL2004544 — Ki = 794.33 nM 6.10
CHEMBL1986943 — Ki = 794.33 nM 6.10
CHEMBL1090360 — Ki = 794.33 nM 6.10
CHEMBL1971021 — Ki = 794.33 nM 6.10
CHEMBL1969588 — Ki = 1000.0 nM 6.00
CHEMBL1992306 — Ki = 1000.0 nM 6.00
CHEMBL1985092 — Ki = 1000.0 nM 6.00
CHEMBL1993424 — Ki = 1000.0 nM 6.00
CHEMBL1979516 — Ki = 1000.0 nM 6.00
CHEMBL1988838 — Ki = 1000.0 nM 6.00
CHEMBL253969 OSI-632 Ki = 1258.93 nM 5.90
CHEMBL1996831 — Ki = 1258.93 nM 5.90
CHEMBL1989029 — Ki = 1584.89 nM 5.80
CHEMBL1975138 — Ki = 1584.89 nM 5.80
CHEMBL2001485 — Ki = 1584.89 nM 5.80
CHEMBL2003456 — Ki = 1584.89 nM 5.80
CHEMBL223360 LINIFANIB Ki = 1584.89 nM 5.80