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Assay Detail

CHEMBL1963833

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ERBB4
ChEMBL ↗
681
Total Activities
669
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Receptor tyrosine-protein kinase erbB-4 (CHEMBL3009) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 681 6.30 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1981725 — — 1 8.60
CHEMBL1991429 — — 1 8.30
CHEMBL1090360 — — 1 8.20
CHEMBL1967878 CENISERTIB 2.0 1 8.10
CHEMBL1997617 — — 1 8.10
CHEMBL2006715 — — 1 8.00
CHEMBL1999749 — — 1 7.80
CHEMBL509032 TAE-684 — 1 7.70
CHEMBL1090356 — — 1 7.70
CHEMBL554 LAPATINIB 4.0 2 7.60
CHEMBL5416410 DASATINIB 4.0 1 7.40
CHEMBL1970879 — — 1 7.30
CHEMBL458997 — — 1 7.10
CHEMBL1995592 — — 1 7.00
CHEMBL1969502 — — 1 7.00
CHEMBL1987034 — — 1 6.90
CHEMBL1988838 — — 1 6.90
CHEMBL939 GEFITINIB 4.0 2 6.80
CHEMBL1993661 — — 1 6.80
CHEMBL363648 TAK-715 2.0 1 6.70
CHEMBL306380 — — 1 6.70
CHEMBL1241473 — — 1 6.70
CHEMBL215152 DEFOSBARASERTIB 2.0 1 6.70
CHEMBL1980297 ILORASERTIB 2.0 1 6.70
CHEMBL475251 R-406 2.0 1 6.50
CHEMBL1980163 — — 1 6.40
CHEMBL396523 — — 1 6.40
CHEMBL243088 — — 1 6.40
CHEMBL244378 — — 1 6.30
CHEMBL1988163 — — 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1981725 — Ki = 2.512 nM 8.60
CHEMBL1991429 — Ki = 5.012 nM 8.30
CHEMBL1090360 — Ki = 6.31 nM 8.20
CHEMBL1967878 CENISERTIB Ki = 7.943 nM 8.10
CHEMBL1997617 — Ki = 7.943 nM 8.10
CHEMBL2006715 — Ki = 10.0 nM 8.00
CHEMBL1999749 — Ki = 15.85 nM 7.80
CHEMBL1090356 — Ki = 19.95 nM 7.70
CHEMBL509032 TAE-684 Ki = 19.95 nM 7.70
CHEMBL554 LAPATINIB Ki = 25.12 nM 7.60
CHEMBL554 LAPATINIB Ki = 25.12 nM 7.60
CHEMBL5416410 DASATINIB Ki = 39.81 nM 7.40
CHEMBL1970879 — Ki = 50.12 nM 7.30
CHEMBL458997 — Ki = 79.43 nM 7.10
CHEMBL1969502 — Ki = 100.0 nM 7.00
CHEMBL1995592 — Ki = 100.0 nM 7.00
CHEMBL1987034 — Ki = 125.89 nM 6.90
CHEMBL1988838 — Ki = 125.89 nM 6.90
CHEMBL1993661 — Ki = 158.49 nM 6.80
CHEMBL939 GEFITINIB Ki = 158.49 nM 6.80
CHEMBL939 GEFITINIB Ki = 158.49 nM 6.80
CHEMBL1980297 ILORASERTIB Ki = 199.53 nM 6.70
CHEMBL215152 DEFOSBARASERTIB Ki = 199.53 nM 6.70
CHEMBL306380 — Ki = 199.53 nM 6.70
CHEMBL1241473 — Ki = 199.53 nM 6.70
CHEMBL363648 TAK-715 Ki = 199.53 nM 6.70
CHEMBL475251 R-406 Ki = 316.23 nM 6.50
CHEMBL396523 — Ki = 398.11 nM 6.40
CHEMBL243088 — Ki = 398.11 nM 6.40
CHEMBL1980163 — Ki = 398.11 nM 6.40
CHEMBL2002165 — Ki = 501.19 nM 6.30
CHEMBL244378 — Ki = 501.19 nM 6.30
CHEMBL1996234 — Ki = 501.19 nM 6.30
CHEMBL1990496 — Ki = 501.19 nM 6.30
CHEMBL1988163 — Ki = 501.19 nM 6.30
CHEMBL1967720 — Ki = 501.19 nM 6.30
CHEMBL1965570 — Ki = 630.96 nM 6.20
CHEMBL2001239 — Ki = 630.96 nM 6.20
CHEMBL1993941 — Ki = 630.96 nM 6.20
CHEMBL1977041 — Ki = 630.96 nM 6.20
CHEMBL1972142 — Ki = 630.96 nM 6.20
CHEMBL1978099 — Ki = 630.96 nM 6.20
CHEMBL1982924 — Ki = 794.33 nM 6.10
CHEMBL1984162 — Ki = 794.33 nM 6.10
CHEMBL1972584 — Ki = 1000.0 nM 6.00
CHEMBL1970317 — Ki = 1000.0 nM 6.00
CHEMBL1996066 — Ki = 1000.0 nM 6.00
CHEMBL1992644 — Ki = 1000.0 nM 6.00
CHEMBL1979516 — Ki = 1000.0 nM 6.00
CHEMBL1972584 — Ki = 1000.0 nM 6.00