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Assay Detail

CHEMBL1964108

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IKBKE
ChEMBL ↗
327
Total Activities
317
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Inhibitor of nuclear factor kappa-B kinase subunit epsilon (CHEMBL3529) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 327 5.76 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1980995 — — 1 8.30
CHEMBL1980407 — — 1 7.70
CHEMBL1980297 ILORASERTIB 2.0 1 7.60
CHEMBL1989708 — — 1 7.60
CHEMBL1983111 — — 1 7.40
CHEMBL1988581 — — 1 7.30
CHEMBL1983715 — — 1 7.20
CHEMBL1972220 — — 1 7.20
CHEMBL475251 R-406 2.0 1 7.00
CHEMBL21156 — — 1 7.00
CHEMBL1973359 — — 1 6.90
CHEMBL1993661 — — 1 6.90
CHEMBL2006564 — — 1 6.80
CHEMBL1991078 — — 1 6.70
CHEMBL1975927 — — 1 6.70
CHEMBL1999484 — — 1 6.60
CHEMBL2000029 — — 1 6.60
CHEMBL482967 CYC-116 1.0 1 6.50
CHEMBL1972346 — — 1 6.40
CHEMBL1983640 — — 1 6.40
CHEMBL242865 — — 1 6.40
CHEMBL1978166 — — 2 6.40
CHEMBL1997335 — — 1 6.30
CHEMBL1825138 — — 2 6.30
CHEMBL1967878 CENISERTIB 2.0 1 6.30
CHEMBL1983575 — — 1 6.30
CHEMBL1982837 — — 1 6.30
CHEMBL1999414 — — 1 6.20
CHEMBL2004290 — — 1 6.20
CHEMBL1996649 — — 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1980995 — Ki = 5.012 nM 8.30
CHEMBL1980407 — Ki = 19.95 nM 7.70
CHEMBL1989708 — Ki = 25.12 nM 7.60
CHEMBL1980297 ILORASERTIB Ki = 25.12 nM 7.60
CHEMBL1983111 — Ki = 39.81 nM 7.40
CHEMBL1988581 — Ki = 50.12 nM 7.30
CHEMBL1972220 — Ki = 63.1 nM 7.20
CHEMBL1983715 — Ki = 63.1 nM 7.20
CHEMBL475251 R-406 Ki = 100.0 nM 7.00
CHEMBL21156 — Ki = 100.0 nM 7.00
CHEMBL1993661 — Ki = 125.89 nM 6.90
CHEMBL1973359 — Ki = 125.89 nM 6.90
CHEMBL2006564 — Ki = 158.49 nM 6.80
CHEMBL1975927 — Ki = 199.53 nM 6.70
CHEMBL1991078 — Ki = 199.53 nM 6.70
CHEMBL2000029 — Ki = 251.19 nM 6.60
CHEMBL1999484 — Ki = 251.19 nM 6.60
CHEMBL482967 CYC-116 Ki = 316.23 nM 6.50
CHEMBL242865 — Ki = 398.11 nM 6.40
CHEMBL1983640 — Ki = 398.11 nM 6.40
CHEMBL1978166 — Ki = 398.11 nM 6.40
CHEMBL1972346 — Ki = 398.11 nM 6.40
CHEMBL1978166 — Ki = 398.11 nM 6.40
CHEMBL1982837 — Ki = 501.19 nM 6.30
CHEMBL1983575 — Ki = 501.19 nM 6.30
CHEMBL1967878 CENISERTIB Ki = 501.19 nM 6.30
CHEMBL1997335 — Ki = 501.19 nM 6.30
CHEMBL1825138 — Ki = 501.19 nM 6.30
CHEMBL1979690 — Ki = 630.96 nM 6.20
CHEMBL1983348 — Ki = 630.96 nM 6.20
CHEMBL1983923 — Ki = 630.96 nM 6.20
CHEMBL1999414 — Ki = 630.96 nM 6.20
CHEMBL2004290 — Ki = 630.96 nM 6.20
CHEMBL1989267 — Ki = 630.96 nM 6.20
CHEMBL1996649 — Ki = 630.96 nM 6.20
CHEMBL1977749 — Ki = 794.33 nM 6.10
CHEMBL1986943 — Ki = 794.33 nM 6.10
CHEMBL1986943 — Ki = 794.33 nM 6.10
CHEMBL2006765 — Ki = 794.33 nM 6.10
CHEMBL522892 DOVITINIB Ki = 794.33 nM 6.10
CHEMBL1964441 — Ki = 794.33 nM 6.10
CHEMBL1977138 — Ki = 1000.0 nM 6.00
CHEMBL1982711 — Ki = 1000.0 nM 6.00
CHEMBL509032 TAE-684 Ki = 1000.0 nM 6.00
CHEMBL1970317 — Ki = 1000.0 nM 6.00
CHEMBL1967998 — Ki = 1000.0 nM 6.00
CHEMBL1996646 — Ki = 1000.0 nM 6.00
CHEMBL1985006 — Ki = 1000.0 nM 6.00
CHEMBL1992581 — Ki = 1000.0 nM 6.00
CHEMBL1995811 — Ki = 1258.93 nM 5.90