Assay Detail
Functional
CHEMBL3584303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1-3B infected in human MT4 cells assessed as inhibition of virus induced cell death measured after 5 days of infection by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Antiviral Activity of Flexibilane and Tigliane Diterpenoids from Stillingia lineata.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.75 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.15 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 8.00 |
| CHEMBL3582007 | — | — | 1 | 7.37 |
| CHEMBL518887 | — | — | 1 | 6.89 |
| CHEMBL3582006 | — | — | 1 | 6.63 |
| CHEMBL3582005 | — | — | 1 | 6.57 |
| CHEMBL141 | LAMIVUDINE | 4.0 | 1 | 5.41 |
| CHEMBL1460 | DIDANOSINE | 4.0 | 1 | 4.97 |
| CHEMBL3582004 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 7.1 | nM | 8.15 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3582007 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL518887 | — | EC50 | = | 129.0 | nM | 6.89 |
| CHEMBL3582006 | — | EC50 | = | 233.0 | nM | 6.63 |
| CHEMBL3582005 | — | EC50 | = | 271.0 | nM | 6.57 |
| CHEMBL141 | LAMIVUDINE | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1460 | DIDANOSINE | EC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3582004 | — | EC50 | > | 85000.0 | nM | - |