Assay Detail
Binding
CHEMBL3607733
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Binding affinity to 5'-FAM-pre-miR-17 (unknown origin) after 4 hrs by fluorescence assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 18 | 5.31 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1434 | MINOCYCLINE | 4.0 | 1 | 6.19 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 6.03 |
| CHEMBL1909452 | APRAMYCIN | 2.0 | 1 | 5.99 |
| CHEMBL529 | AZITHROMYCIN | 4.0 | 1 | 5.79 |
| CHEMBL184618 | FRAMYCETIN | 3.0 | 1 | 5.73 |
| CHEMBL6067485 | GENTAMICIN | 4.0 | 1 | 5.30 |
| CHEMBL469912 | PUROMYCIN | 2.0 | 1 | 5.23 |
| CHEMBL1517 | OXYTETRACYCLINE | 4.0 | 1 | 5.21 |
| CHEMBL372795 | STREPTOMYCIN | 4.0 | 1 | 4.73 |
| CHEMBL427409 | NEAMINE | — | 1 | 4.60 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 4.56 |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | 4.36 |
| CHEMBL1167 | SPECTINOMYCIN | 4.0 | 1 | - |
| CHEMBL1753 | CLINDAMYCIN | 4.0 | 1 | - |
| CHEMBL1447 | LINCOMYCIN | 4.0 | 1 | - |
| CHEMBL126 | LINEZOLID | 4.0 | 1 | - |
| CHEMBL176 | BEKANAMYCIN | 3.0 | 1 | - |
| CHEMBL130 | CHLORAMPHENICOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1434 | MINOCYCLINE | Kd | = | 651.0 | nM | 6.19 |
| CHEMBL1200699 | DOXYCYCLINE | Kd | = | 940.0 | nM | 6.03 |
| CHEMBL1909452 | APRAMYCIN | Kd | = | 1030.0 | nM | 5.99 |
| CHEMBL529 | AZITHROMYCIN | Kd | = | 1630.0 | nM | 5.79 |
| CHEMBL184618 | FRAMYCETIN | Kd | = | 1880.0 | nM | 5.73 |
| CHEMBL6067485 | GENTAMICIN | Kd | = | 4980.0 | nM | 5.30 |
| CHEMBL469912 | PUROMYCIN | Kd | = | 5850.0 | nM | 5.23 |
| CHEMBL1517 | OXYTETRACYCLINE | Kd | = | 6220.0 | nM | 5.21 |
| CHEMBL372795 | STREPTOMYCIN | Kd | = | 18500.0 | nM | 4.73 |
| CHEMBL427409 | NEAMINE | Kd | = | 24900.0 | nM | 4.60 |
| CHEMBL532 | ERYTHROMYCIN | Kd | = | 27400.0 | nM | 4.56 |
| CHEMBL370143 | PAROMOMYCIN | Kd | = | 44000.0 | nM | 4.36 |
| CHEMBL1167 | SPECTINOMYCIN | Kd | - | — | - | |
| CHEMBL1753 | CLINDAMYCIN | Kd | - | — | - | |
| CHEMBL1447 | LINCOMYCIN | Kd | - | — | - | |
| CHEMBL126 | LINEZOLID | Kd | - | — | - | |
| CHEMBL176 | BEKANAMYCIN | Kd | - | — | - | |
| CHEMBL130 | CHLORAMPHENICOL | Kd | - | — | - |