Assay Detail
Binding
CHEMBL4018627
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Inhibition of recombinant human FGFR3 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.95 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.26 |
| CHEMBL4073545 | — | — | 1 | 8.10 |
| CHEMBL4075917 | — | — | 1 | 7.80 |
| CHEMBL4084388 | — | — | 1 | 7.64 |
| CHEMBL4067871 | — | — | 1 | 7.64 |
| CHEMBL4074407 | — | — | 1 | 7.56 |
| CHEMBL4062877 | — | — | 1 | 7.56 |
| CHEMBL4076118 | — | — | 1 | 7.45 |
| CHEMBL4077448 | — | — | 1 | 7.23 |
| CHEMBL4105329 | — | — | 1 | 7.14 |
| CHEMBL4082721 | — | — | 1 | 7.03 |
| CHEMBL4084547 | — | — | 1 | 6.60 |
| CHEMBL4086068 | — | — | 1 | 6.55 |
| CHEMBL4094883 | — | — | 1 | 6.41 |
| CHEMBL4095830 | — | — | 1 | 6.40 |
| CHEMBL4071491 | — | — | 1 | 6.37 |
| CHEMBL4100031 | — | — | 1 | 6.36 |
| CHEMBL4060706 | — | — | 1 | 6.25 |
| CHEMBL4077119 | — | — | 1 | 6.23 |
| CHEMBL4078176 | — | — | 1 | 6.01 |
| CHEMBL4062871 | — | — | 1 | 5.44 |
| CHEMBL4075768 | — | — | 1 | - |
| CHEMBL4092280 | — | — | 1 | - |
| CHEMBL4082577 | — | — | 1 | - |
| CHEMBL4102355 | — | — | 1 | - |
| CHEMBL4064545 | — | — | 1 | - |
| CHEMBL4068491 | — | — | 1 | - |
| CHEMBL4100109 | — | — | 1 | - |
| CHEMBL4101681 | — | — | 1 | - |
| CHEMBL4091460 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4073545 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4075917 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL4084388 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL4067871 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4074407 | — | IC50 | = | 27.6 | nM | 7.56 |
| CHEMBL4062877 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL4076118 | — | IC50 | = | 35.3 | nM | 7.45 |
| CHEMBL4077448 | — | IC50 | = | 58.4 | nM | 7.23 |
| CHEMBL4105329 | — | IC50 | = | 73.1 | nM | 7.14 |
| CHEMBL4082721 | — | IC50 | = | 93.9 | nM | 7.03 |
| CHEMBL4084547 | — | IC50 | = | 250.5 | nM | 6.60 |
| CHEMBL4086068 | — | IC50 | = | 279.9 | nM | 6.55 |
| CHEMBL4094883 | — | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL4095830 | — | IC50 | = | 401.5 | nM | 6.40 |
| CHEMBL4071491 | — | IC50 | = | 430.5 | nM | 6.37 |
| CHEMBL4100031 | — | IC50 | = | 433.8 | nM | 6.36 |
| CHEMBL4060706 | — | IC50 | = | 560.7 | nM | 6.25 |
| CHEMBL4077119 | — | IC50 | = | 591.5 | nM | 6.23 |
| CHEMBL4078176 | — | IC50 | = | 969.7 | nM | 6.01 |
| CHEMBL4062871 | — | IC50 | = | 3653.5 | nM | 5.44 |
| CHEMBL4101542 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4082023 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4102447 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4063010 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4083543 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4091460 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4101681 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4100109 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4068491 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4064545 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4102355 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4082577 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4092280 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4075768 | — | IC50 | > | 1000.0 | nM | - |