Assay Detail
Binding
CHEMBL4880055
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GPCRScan assay: inhibition of Beta1
184
Total Activities
176
Compounds Tested
2
Activity Types
12
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SGC PDSP GPCRScan assays
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 176 | - | - |
| Ki | 8 | 5.46 | 5.72 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Parental cells | Parental cells | - | — | CHO Flp-In |
| PMID | PMID | - | — | 3038128/9112080/15060759/2566701 |
| Protein length | Protein length | - | — | full-length |
| Radioligand conc. used [nM] | Radioligand conc. used [nM] | - | — | 0.1 – 0.2 |
| Radioligand Kd | Radioligand Kd | 0.1 | nM | — |
| Radioligand name | Radioligand name | - | — | [125I]-Pindolol |
| Radioligand pKd | Radioligand pKd | 10.06 | — | — |
| Radioligand pKd ± SEM | Radioligand pKd ± SEM | 0.09 | — | — |
| Reference ligand | Reference ligand | - | — | Alprenolol |
| Reference ligand Ki | Reference ligand Ki | 1.85 | nM | — |
| Reference ligand pKi | Reference ligand pKi | 8.73 | — | — |
| Reference ligand pKi ± SEM | Reference ligand pKi ± SEM | 0.03 | — | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456123 | BI 639667 | 1.0 | 3 | 5.72 |
| CHEMBL3582478 | MSD-CYP11B2 | — | 3 | 5.63 |
| CHEMBL3617968 | BAY-678 | — | 3 | 5.30 |
| CHEMBL3480577 | UCSF924 | — | 3 | 5.00 |
| CHEMBL4564312 | BAY-786 | — | 1 | - |
| CHEMBL4535474 | BAY-293 | — | 1 | - |
| CHEMBL4448899 | BAY-876 | — | 1 | - |
| CHEMBL4552180 | BAY-588 | — | 1 | - |
| CHEMBL4445670 | BAY-885 | — | 1 | - |
| CHEMBL4455582 | BAY-693 | — | 1 | - |
| CHEMBL4630644 | BAY-386 | — | 1 | - |
| CHEMBL4630643 | BAY-448 | — | 1 | - |
| CHEMBL3907057 | BAY-826 | — | 1 | - |
| CHEMBL4526351 | BAY-309 | — | 1 | - |
| CHEMBL4096813 | — | — | 1 | - |
| CHEMBL4084419 | — | — | 1 | - |
| CHEMBL4520674 | BAY-677 | — | 1 | - |
| CHEMBL4537788 | BAY-784 | — | 1 | - |
| CHEMBL4516843 | BAY-207 | — | 1 | - |
| CHEMBL4521594 | BAY-1797 | — | 1 | - |
| CHEMBL4539943 | BAY-694 | — | 1 | - |
| CHEMBL4585243 | BAY-7598 | — | 1 | - |
| CHEMBL4522773 | BAY-827 | — | 1 | - |
| CHEMBL4593677 | BAY-474 | — | 1 | - |
| CHEMBL4513786 | A-545 | — | 1 | - |
| CHEMBL111612 | ABT-546 | — | 1 | - |
| CHEMBL4526341 | A-108 | — | 1 | - |
| CHEMBL4586794 | ABT-100 | — | 1 | - |
| CHEMBL3701197 | A-226 | — | 1 | - |
| CHEMBL3697701 | A-079 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456123 | BI 639667 | Ki | = | 1883.65 | nM | 5.72 |
| CHEMBL4456123 | BI 639667 | Ki | = | 1905.46 | nM | 5.72 |
| CHEMBL3582478 | MSD-CYP11B2 | Ki | = | 2344.23 | nM | 5.63 |
| CHEMBL3582478 | MSD-CYP11B2 | Ki | = | 2370.28 | nM | 5.62 |
| CHEMBL3617968 | BAY-678 | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL3617968 | BAY-678 | Ki | = | 5454.0 | nM | 5.26 |
| CHEMBL3480577 | UCSF924 | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4534980 | (S)-ZINC-3573 | Inhibition | = | 4.16 | % | - |
| CHEMBL3590047 | IPP/CNRS-A019 | Inhibition | = | 23.86 | % | - |
| CHEMBL4520293 | (R)-ZINC-3573 | Inhibition | = | 30.73 | % | - |
| CHEMBL4456585 | WM-1119 | Inhibition | = | -0.13 | % | - |
| CHEMBL4630642 | BAY-974 | Inhibition | = | -7.79 | % | - |
| CHEMBL4580220 | BAY-3827 | Inhibition | = | 1.59 | % | - |
| CHEMBL4538591 | BAY-440 | Inhibition | = | -6.2 | % | - |
| CHEMBL4537673 | BAY-985 | Inhibition | = | 24.31 | % | - |
| CHEMBL4592872 | BAY-897 | Inhibition | = | -7.28 | % | - |
| CHEMBL4458424 | BAY-899 | Inhibition | = | 11.3 | % | - |
| CHEMBL4643852 | BAY-6672 | Inhibition | = | 15.67 | % | - |
| CHEMBL4514203 | BAY-390 | Inhibition | = | 20.23 | % | - |
| CHEMBL4635134 | GSK620 | Inhibition | = | -6.19 | % | - |
| CHEMBL4636881 | GSK046 | Inhibition | = | -6.85 | % | - |
| CHEMBL4635540 | GSK791 | Inhibition | = | 2.98 | % | - |
| CHEMBL4648362 | GSK789 | Inhibition | = | 1.68 | % | - |
| CHEMBL4555711 | BAY-9897 | Inhibition | = | -0.24 | % | - |
| CHEMBL4551635 | BAY-069 | Inhibition | = | -5.52 | % | - |
| CHEMBL4088216 | TP-030-1 | Inhibition | = | 5.21 | % | - |
| CHEMBL4549667 | TP-030-2 | Inhibition | = | 12.02 | % | - |
| CHEMBL4638406 | BAY-3153 | Inhibition | = | -26.17 | % | - |
| CHEMBL4639128 | GSK778 | Inhibition | = | 4.82 | % | - |
| CHEMBL3137331 | DEFACTINIB | Inhibition | = | -0.83 | % | - |
| CHEMBL4445645 | — | Inhibition | = | -2.67 | % | - |
| CHEMBL4577237 | BI 9446 | Inhibition | = | 29.73 | % | - |
| CHEMBL4530740 | BI 1950 | Inhibition | = | 24.11 | % | - |
| CHEMBL4552554 | PF-04475866 | Inhibition | = | -6.66 | % | - |
| CHEMBL3286797 | PF-04418948 | Inhibition | = | -12.18 | % | - |
| CHEMBL2204283 | MSD-M1PAM-NC | Inhibition | = | -5.76 | % | - |
| CHEMBL1800285 | MSD-M1PAM | Inhibition | = | 16.22 | % | - |
| CHEMBL4638939 | GSK943 | Inhibition | = | 6.93 | % | - |
| CHEMBL4637208 | GSK973 | Inhibition | = | 6.03 | % | - |
| CHEMBL3589752 | IPP/CNRS-A017 | Inhibition | = | -5.782 | % | - |
| CHEMBL4545807 | BAY-070 | Inhibition | = | 19.91 | % | - |
| CHEMBL4798829 | — | Inhibition | = | 20.93 | % | - |
| CHEMBL4536197 | A-486 | Inhibition | = | -4.4 | % | - |
| CHEMBL4282264 | A-485 | Inhibition | = | -5.22 | % | - |
| CHEMBL4561806 | BTZO-4 | Inhibition | = | -1.521 | % | - |
| CHEMBL4516611 | BTZO-1 | Inhibition | = | -8.559 | % | - |
| CHEMBL4063249 | TP-021n | Inhibition | = | 4.98 | % | - |
| CHEMBL4075278 | — | Inhibition | = | 3.3 | % | - |
| CHEMBL4647642 | BAY-173 | Inhibition | = | 6.12 | % | - |
| CHEMBL4460070 | ZINC32547799 | Inhibition | = | -3.07 | % | - |