Assay Detail
Functional
CHEMBL5330064
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Cytotoxicity against human THP-1 cells assessed as inhibition of cell growth incubated for 72 hrs by resazurin staining based analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, electrochemistry and anti-trypanosomatid hit/lead identification of nitrofuranylazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.49 | 4.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 4.83 |
| CHEMBL5425056 | — | — | 1 | 4.78 |
| CHEMBL5433031 | — | — | 1 | 4.64 |
| CHEMBL4870182 | — | — | 1 | 4.57 |
| CHEMBL5419390 | — | — | 1 | 4.33 |
| CHEMBL5421631 | — | — | 1 | 4.20 |
| CHEMBL351937 | — | — | 1 | 4.09 |
| CHEMBL5395967 | — | — | 1 | - |
| CHEMBL5430637 | — | — | 1 | - |
| CHEMBL5417965 | — | — | 1 | - |
| CHEMBL5396329 | — | — | 1 | - |
| CHEMBL5423743 | — | — | 1 | - |
| CHEMBL5406125 | — | — | 1 | - |
| CHEMBL5437595 | — | — | 1 | - |
| CHEMBL5418807 | — | — | 1 | - |
| CHEMBL869 | NITROFURAZONE | 4.0 | 1 | - |
| CHEMBL1103 | FURAZOLIDONE | 4.0 | 1 | - |
| CHEMBL110 | BENZNIDAZOLE | 4.0 | 1 | - |
| CHEMBL5418513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 14860.0 | nM | 4.83 |
| CHEMBL5425056 | — | IC50 | = | 16750.0 | nM | 4.78 |
| CHEMBL5433031 | — | IC50 | = | 22870.0 | nM | 4.64 |
| CHEMBL4870182 | — | IC50 | = | 26690.0 | nM | 4.57 |
| CHEMBL5419390 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL5421631 | — | IC50 | = | 63370.0 | nM | 4.20 |
| CHEMBL351937 | — | IC50 | = | 80920.0 | nM | 4.09 |
| CHEMBL5395967 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5430637 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5417965 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5396329 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5423743 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5406125 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5437595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5418807 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL869 | NITROFURAZONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL1103 | FURAZOLIDONE | IC50 | > | 100000.0 | nM | - |
| CHEMBL110 | BENZNIDAZOLE | IC50 | > | 100000.0 | nM | - |
| CHEMBL5418513 | — | IC50 | > | 100000.0 | nM | - |