Assay Detail
Binding
CHEMBL641389
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Inhibitory activity against acetylcholinesterase in rat striatal preparation
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.87 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.50 |
| CHEMBL345442 | — | — | 1 | 5.17 |
| CHEMBL155603 | — | — | 1 | 4.70 |
| CHEMBL154228 | — | — | 1 | 4.70 |
| CHEMBL350692 | — | — | 1 | 4.54 |
| CHEMBL154257 | — | — | 1 | 4.24 |
| CHEMBL155109 | — | — | 1 | 4.21 |
| CHEMBL357553 | — | — | 1 | - |
| CHEMBL154488 | — | — | 1 | - |
| CHEMBL347336 | — | — | 1 | - |
| CHEMBL155211 | — | — | 1 | - |
| CHEMBL154297 | — | — | 1 | - |
| CHEMBL345607 | — | — | 1 | - |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | - |
| CHEMBL152842 | — | — | 1 | - |
| CHEMBL346142 | — | — | 1 | - |
| CHEMBL154735 | — | — | 1 | - |
| CHEMBL348034 | — | — | 1 | - |
| CHEMBL347933 | — | — | 1 | - |
| CHEMBL157971 | — | — | 1 | - |
| CHEMBL356922 | — | — | 1 | - |
| CHEMBL134 | CLONIDINE | 4.0 | 1 | - |
| CHEMBL155460 | — | — | 1 | - |
| CHEMBL29835 | BESIPIRDINE | 2.0 | 1 | - |
| CHEMBL10316 | IDAZOXAN | 3.0 | 1 | - |
| CHEMBL154945 | — | — | 1 | - |
| CHEMBL155359 | — | — | 1 | - |
| CHEMBL435034 | — | — | 1 | - |
| CHEMBL153847 | — | — | 1 | - |
| CHEMBL346021 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL345442 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL155603 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL154228 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL350692 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL154257 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL155109 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL345251 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL346142 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL152748 | — | IC50 | - | nM | - | |
| CHEMBL7634 | OXOTREMORINE | IC50 | - | nM | - | |
| CHEMBL157902 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL569713 | SCOPOLAMINE | IC50 | - | nM | - | |
| CHEMBL154488 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348034 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL154735 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL154319 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348716 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347199 | — | IC50 | - | nM | - | |
| CHEMBL345439 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL348865 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL351760 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL154541 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL152362 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347666 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347914 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL356922 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL346021 | — | IC50 | - | nM | - | |
| CHEMBL153847 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL435034 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL155359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL154945 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL10316 | IDAZOXAN | IC50 | - | nM | - | |
| CHEMBL29835 | BESIPIRDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL155460 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL134 | CLONIDINE | IC50 | - | nM | - | |
| CHEMBL152842 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL157971 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347933 | — | IC50 | - | nM | - | |
| CHEMBL357553 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL347336 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL155211 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL154297 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345607 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL15245 | YOHIMBINE | IC50 | - | nM | - |