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Assay Detail

CHEMBL716502

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4)
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Metabotropic glutamate receptor 4 (CHEMBL2736)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Ligands for glutamate receptors: design and therapeutic prospects.
Bräuner-Osborne H, Egebjerg J, Nielsen EO, Madsen U, Krogsgaard-Larsen P.
J Med Chem (2000) 43 : 2609 -2645
PubMed 10893301 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 44 4.79 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL33567 1 6.04
CHEMBL277475 1 5.28
CHEMBL329236 1 5.06
CHEMBL575060 GLUTAMIC ACID 3.0 1 4.77
CHEMBL275079 LY-379268 1 4.68
CHEMBL432038 1 4.66
CHEMBL330097 1 4.66
CHEMBL90501 1 4.64
CHEMBL88612 1 4.58
CHEMBL280563 1 4.30
CHEMBL279838 1 4.06
CHEMBL88553 1 -
CHEMBL41221 1 -
CHEMBL71898 1 -
CHEMBL327783 1 -
CHEMBL39221 1 -
CHEMBL279956 QUISQUALATE 1 -
CHEMBL313938 1 -
CHEMBL315663 1 -
CHEMBL88184 1 -
CHEMBL94990 1 -
CHEMBL43412 1 -
CHEMBL299683 1 -
CHEMBL315268 1 -
CHEMBL40123 1 -
CHEMBL89293 1 -
CHEMBL126608 1 -
CHEMBL40086 1 -
CHEMBL2021372 1 -
CHEMBL297150 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL33567 Ki = 910.0 nM 6.04
CHEMBL277475 Ki = 5200.0 nM 5.28
CHEMBL329236 Ki = 8800.0 nM 5.06
CHEMBL575060 GLUTAMIC ACID Ki = 17000.0 nM 4.77
CHEMBL275079 LY-379268 Ki = 21000.0 nM 4.68
CHEMBL432038 Ki = 22000.0 nM 4.66
CHEMBL330097 Ki = 22000.0 nM 4.66
CHEMBL90501 Ki = 23000.0 nM 4.64
CHEMBL88612 Ki = 26000.0 nM 4.58
CHEMBL280563 Ki = 50000.0 nM 4.30
CHEMBL279838 Ki = 88000.0 nM 4.06
CHEMBL41221 Ki = 470000.0 nM -
CHEMBL88124 Ki > 1000000.0 nM -
CHEMBL88553 Ki > 100000.0 nM -
CHEMBL315032 Ki > 1000000.0 nM -
CHEMBL66654 Ki > 100000.0 nM -
CHEMBL313394 Ki > 1000000.0 nM -
CHEMBL41013 Ki > 1000000.0 nM -
CHEMBL8759 EGLUMETAD Ki > 100000.0 nM -
CHEMBL38499 Ki > 1000000.0 nM -
CHEMBL444589 Ki > 1000000.0 nM -
CHEMBL305406 Ki > 100000.0 nM -
CHEMBL313713 Ki > 1000000.0 nM -
CHEMBL284895 Ki > 1000000.0 nM -
CHEMBL39338 Ki > 300000.0 nM -
CHEMBL88804 (S)-2-AMINOADIPIC ACID Ki > 3000000.0 nM -
CHEMBL88999 Ki > 100000.0 nM -
CHEMBL43412 Ki > 300000.0 nM -
CHEMBL297150 Ki > 1000000.0 nM -
CHEMBL2021372 Ki > 1000000.0 nM -
CHEMBL40086 Ki > 300000.0 nM -
CHEMBL126608 Ki > 1000000.0 nM -
CHEMBL89293 Ki > 100000.0 nM -
CHEMBL40123 Ki > 300000.0 nM -
CHEMBL315268 Ki > 1000000.0 nM -
CHEMBL299683 Ki > 1000000.0 nM -
CHEMBL71898 Ki = 1000000.0 nM -
CHEMBL94990 Ki > 1000000.0 nM -
CHEMBL88184 Ki > 1000000.0 nM -
CHEMBL315663 Ki > 1000000.0 nM -
CHEMBL313938 Ki > 1000000.0 nM -
CHEMBL279956 QUISQUALATE Ki = 1000000.0 nM -
CHEMBL39221 Ki > 1000000.0 nM -
CHEMBL327783 Ki > 100000.0 nM -