Assay Detail
Functional
CHEMBL818955
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The compound was tested for its effective concentration required to reduce virus plaque formation by using TK (thymidine kinase -deficient) -Varicella-Zoster virus YS/R strain
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of a terminal halogen substitution in the side-chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 4.83 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143184 | — | — | 1 | 5.60 |
| CHEMBL3143180 | — | — | 1 | 5.02 |
| CHEMBL3143178 | — | — | 1 | 4.89 |
| CHEMBL3143183 | — | — | 1 | 4.64 |
| CHEMBL3143181 | — | — | 1 | 4.51 |
| CHEMBL3143185 | — | — | 1 | 4.30 |
| CHEMBL144817 | — | — | 1 | - |
| CHEMBL3143179 | — | — | 1 | - |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL3143182 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143184 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3143180 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL3143178 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3143183 | — | EC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL3143181 | — | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL3143185 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL144817 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3143179 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 125000.0 | nM | - |
| CHEMBL3143182 | — | EC50 | > | 50000.0 | nM | - |