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Compound Detail

CHEMBL1369254

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Cc1csc(NC(=O)c2c(O)c3c(n(CC(C)C)c2=O)CCCC3)n1

Basic Information

ChEMBL ID CHEMBL1369254
Phase Preclinical
Structure Type MOL
InChI Key YMZKZLDERWRGNO-UHFFFAOYSA-N
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

361.5
MW (Da)
3.11
ALogP
6
HBA
2
HBD
84.2
PSA (Ų)
0.88
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H23N3O3S
MW 361.47
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -1.64

Activity Summary

EC50 3 meas. best 4.96
IC50 1 meas. best 5.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.31 5.31 4901.0 1
Streptokinase A
CHEMBL1293228
EC50 4.96 4.96 10900.0 1
Streptococcus sp. 'group A'
CHEMBL612389
EC50 4.96 4.96 11022.0 1
Streptococcus
CHEMBL612313
EC50 4.76 4.76 17258.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine