Compound Detail
CHEMBL1468490
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Basic Information
| ChEMBL ID | CHEMBL1468490 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AWCKGOAGXDNJHN-UHFFFAOYSA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
331.8
MW (Da)
2.65
ALogP
3
HBA
0
HBD
46.6
PSA (Ų)
0.78
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.66
IC50 2 meas. best 5.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 CHEMBL4018 | IC50 | 5.24 | 5.24 | 5722.0 | 1 |
| Neuropeptide Y receptor type 1 CHEMBL4777 | IC50 | 5.11 | 5.11 | 7817.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.66 | 4.66 | 21963.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.64 | 4.64 | 22978.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 2 | IC50 | = | 5722.0 | nM | 5.24 | PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of ne... | - |
| Neuropeptide Y receptor type 1 | IC50 | = | 7817.0 | nM | 5.11 | PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NP... | - |
| Zinc finger protein mex-5 | EC50 | = | 21963.0 | nM | 4.66 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| RNA-binding protein pos-1 | EC50 | = | 22978.0 | nM | 4.64 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Data from ChEMBL 36 via Core Engine