Compound Detail
CHEMBL1553837
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Basic Information
| ChEMBL ID | CHEMBL1553837 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JEWJHTTZILLULZ-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
311.3
MW (Da)
1.25
ALogP
5
HBA
2
HBD
77.8
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.26
EC50 2 meas. best 4.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 CHEMBL1293302 | IC50 | 5.26 | 5.26 | 5514.0 | 1 |
| Protein Rev CHEMBL1293282 | IC50 | 5.07 | 5.07 | 8440.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.77 | 4.77 | 17027.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.71 | 4.71 | 19645.0 | 1 |
| Polyadenylate-binding protein 1 CHEMBL1293286 | IC50 | 4.32 | 4.32 | 47700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 | IC50 | = | 5514.0 | nM | 5.26 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Protein Rev | IC50 | = | 8440.0 | nM | 5.07 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarizati... | - |
| Zinc finger protein mex-5 | EC50 | = | 17027.0 | nM | 4.77 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| RNA-binding protein pos-1 | EC50 | = | 19645.0 | nM | 4.71 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| Polyadenylate-binding protein 1 | IC50 | = | 47700.0 | nM | 4.32 | PUBCHEM_BIOASSAY: Dose-response confirmation of microRNA-mediated mRNA deacetyla... | - |
Data from ChEMBL 36 via Core Engine