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Compound Detail

CHEMBL1559535

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Cc1cc(N2CCNCC2)nc2ccccc12

Basic Information

ChEMBL ID CHEMBL1559535
Phase Preclinical
Structure Type MOL
InChI Key LCRABWZMGNEZJV-UHFFFAOYSA-N
3
Targets
5
Activities
2
Assay Types
0
PK Parameters
10
Publications
0
Known Names

Molecular Properties

227.3
MW (Da)
1.95
ALogP
3
HBA
1
HBD
28.2
PSA (Ų)
0.81
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H17N3
MW 227.31
Aromatic Rings 2
Heavy Atoms 17
NP-Likeness -1.43

Activity Summary

Ki 3 meas. best 6.66
IC50 2 meas. best 4.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL213
Ki 6.66 6.655 220.0 2
Unchecked
CHEMBL612545
IC50 4.03 4.03 93711.3 1
Neutrophil cytosol factor 1
CHEMBL1613743
Ki 2.97 2.97 1070000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL3988442 Unchecked 5
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M4 2
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M3 2
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M2 2
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M1 2
31922756 10.1021/acs.jmedchem.9b01492 Neutrophil cytosol factor 1 2
- 10.6019/CHEMBL4513160 Pseudomonas aeruginosa 2
23614494 10.1021/jm400561w Beta-1 adrenergic receptor 1
23517028 10.1021/jm400140q Beta-1 adrenergic receptor 1
- 10.6019/CHEMBL4513160 Acinetobacter baumannii 1

Data from ChEMBL 36 via Core Engine