Compound Detail
CHEMBL1575634
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Basic Information
| ChEMBL ID | CHEMBL1575634 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ONQJIKRHRHYBER-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
347.8
MW (Da)
2.60
ALogP
3
HBA
3
HBD
70.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.73
IC50 2 meas. best 4.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Streptokinase A CHEMBL1293228 | EC50 | 6.73 | 6.73 | 187.0 | 1 |
| Streptococcus sp. 'group A' CHEMBL612389 | EC50 | 6.44 | 6.44 | 362.0 | 1 |
| Streptococcus CHEMBL612313 | EC50 | 5.96 | 5.96 | 1087.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.66 | 4.66 | 21866.0 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | IC50 | 4.59 | 4.59 | 25843.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Streptokinase A | EC50 | = | 187.0 | nM | 6.73 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
| Streptococcus sp. 'group A' | EC50 | = | 362.0 | nM | 6.44 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Iden... | - |
| Streptococcus | EC50 | = | 1087.0 | nM | 5.96 | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Response HTS to Identify... | - |
| Unchecked | IC50 | = | 21866.0 | nM | 4.66 | PubChem BioAssay. QFRET-based biochemical high throughput dose response assay to... | - |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | IC50 | = | 25843.4 | nM | 4.59 | PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibito... | - |
Data from ChEMBL 36 via Core Engine