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Compound Detail

CHEMBL1831286

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CCC(c1ccc(O)c(OC)c1)c1cccc(O)c1O

Basic Information

ChEMBL ID CHEMBL1831286
Phase Preclinical
Structure Type MOL
InChI Key SHJXYTKJNPPAHC-UHFFFAOYSA-N
6
Targets
7
Activities
1
Assay Types
0
PK Parameters
13
Publications
0
Known Names

Molecular Properties

274.3
MW (Da)
3.35
ALogP
4
HBA
3
HBD
69.9
PSA (Ų)
0.75
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H18O4
MW 274.32
Aromatic Rings 2
Heavy Atoms 20
NP-Likeness 0.62

Activity Summary

IC50 7 meas. best 5.63

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Tyrosinase
CHEMBL1973
IC50 5.63 5.63 2320.0 1
Cholinesterase
CHEMBL1914
IC50 5.55 5.55 2820.0 1
Acetylcholinesterase
CHEMBL220
IC50 5.25 5.25 5660.0 1
Radical scavenging activity
CHEMBL613712
IC50 5.24 5.24 5800.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 5.21 5.14 6170.0 2
Unchecked
CHEMBL612545
IC50 4.32 4.32 47870.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21843909 10.1016/j.ejmech.2011.07.041 NON-PROTEIN TARGET 12
21843909 10.1016/j.ejmech.2011.07.041 Radical scavenging activity 1
35395370 10.1016/j.bmcl.2022.128722 Acetylcholinesterase 1
35395370 10.1016/j.bmcl.2022.128722 Cholinesterase 1
35395370 10.1016/j.bmcl.2022.128722 Unchecked 1
35395370 10.1016/j.bmcl.2022.128722 Tyrosinase 1
35395370 10.1016/j.bmcl.2022.128722 PC-3 1
35395370 10.1016/j.bmcl.2022.128722 Escherichia coli 1
35395370 10.1016/j.bmcl.2022.128722 Klebsiella pneumoniae 1
35395370 10.1016/j.bmcl.2022.128722 Staphylococcus aureus 1
35395370 10.1016/j.bmcl.2022.128722 Enterococcus faecalis 1
35395370 10.1016/j.bmcl.2022.128722 Candida albicans 1
35395370 10.1016/j.bmcl.2022.128722 Cyberlindnera jadinii 1

Data from ChEMBL 36 via Core Engine