Compound Detail
CHEMBL2007603
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Basic Information
| ChEMBL ID | CHEMBL2007603 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AMVPASHAQNNOFN-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
350.3
MW (Da)
4.43
ALogP
3
HBA
2
HBD
66.9
PSA (Ų)
0.67
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cyclin-dependent kinase 8 CHEMBL5719 | Ki | 7.1 | 7.1 | 79.4 | 1 |
| Dual specificity protein kinase CLK4 CHEMBL4203 | Ki | 7.0 | 7.0 | 100.0 | 1 |
| Activin receptor type-1 CHEMBL5903 | Ki | 5.8 | 5.8 | 1584.9 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B CHEMBL5543 | Ki | 5.7 | 5.7 | 1995.3 | 1 |
| Dual specificity protein kinase CLK2 CHEMBL4225 | Ki | 5.5 | 5.5 | 3162.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 8 | Ki | = | 79.43 | nM | 7.1 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Dual specificity protein kinase CLK4 | Ki | = | 100.0 | nM | 7.0 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Activin receptor type-1 | Ki | = | 1584.89 | nM | 5.8 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Ki | = | 1995.26 | nM | 5.7 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
| Dual specificity protein kinase CLK2 | Ki | = | 3162.28 | nM | 5.5 | PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... | - |
Data from ChEMBL 36 via Core Engine