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Assay Detail

CHEMBL1963799

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK1B
ChEMBL ↗
369
Total Activities
358
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Dual specificity tyrosine-phosphorylation-regulated kinase 1B (CHEMBL5543) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 369 5.93 9.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1965660 — — 2 9.20
CHEMBL1980407 — — 1 9.00
CHEMBL1981133 — — 1 8.70
CHEMBL2007574 — — 1 8.70
CHEMBL1986943 — — 2 8.60
CHEMBL1982711 — — 1 8.40
CHEMBL1980995 — — 1 8.30
CHEMBL1995811 — — 1 8.30
CHEMBL2006439 — — 1 8.10
CHEMBL225519 — — 1 8.00
CHEMBL1967252 — — 1 7.90
CHEMBL1991078 — — 1 7.80
CHEMBL1999484 — — 1 7.80
CHEMBL1998470 — — 1 7.80
CHEMBL1988581 — — 1 7.80
CHEMBL1971289 — — 1 7.80
CHEMBL1973720 — — 2 7.80
CHEMBL1983575 — — 1 7.70
CHEMBL1969151 — — 1 7.60
CHEMBL1977138 — — 1 7.60
CHEMBL1870106 — — 1 7.50
CHEMBL1980391 RG-1530 1.0 1 7.50
CHEMBL2006450 — — 1 7.40
CHEMBL1987535 — — 1 7.40
CHEMBL1973868 — — 1 7.30
CHEMBL1991410 — — 1 7.30
CHEMBL1988141 — — 1 7.20
CHEMBL1973359 — — 1 7.10
CHEMBL1993877 — — 1 7.00
CHEMBL1996702 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1965660 — Ki = 0.631 nM 9.20
CHEMBL1965660 — Ki = 0.631 nM 9.20
CHEMBL1980407 — Ki = 1.0 nM 9.00
CHEMBL2007574 — Ki = 1.995 nM 8.70
CHEMBL1981133 — Ki = 1.995 nM 8.70
CHEMBL1986943 — Ki = 2.512 nM 8.60
CHEMBL1986943 — Ki = 2.512 nM 8.60
CHEMBL1982711 — Ki = 3.981 nM 8.40
CHEMBL1995811 — Ki = 5.012 nM 8.30
CHEMBL1980995 — Ki = 5.012 nM 8.30
CHEMBL2006439 — Ki = 7.943 nM 8.10
CHEMBL225519 — Ki = 10.0 nM 8.00
CHEMBL1967252 — Ki = 12.59 nM 7.90
CHEMBL1999484 — Ki = 15.85 nM 7.80
CHEMBL1988581 — Ki = 15.85 nM 7.80
CHEMBL1971289 — Ki = 15.85 nM 7.80
CHEMBL1998470 — Ki = 15.85 nM 7.80
CHEMBL1991078 — Ki = 15.85 nM 7.80
CHEMBL1973720 — Ki = 15.85 nM 7.80
CHEMBL1973720 — Ki = 15.85 nM 7.80
CHEMBL1983575 — Ki = 19.95 nM 7.70
CHEMBL1977138 — Ki = 25.12 nM 7.60
CHEMBL1969151 — Ki = 25.12 nM 7.60
CHEMBL1980391 RG-1530 Ki = 31.62 nM 7.50
CHEMBL1870106 — Ki = 31.62 nM 7.50
CHEMBL2006450 — Ki = 39.81 nM 7.40
CHEMBL1987535 — Ki = 39.81 nM 7.40
CHEMBL1973868 — Ki = 50.12 nM 7.30
CHEMBL1991410 — Ki = 50.12 nM 7.30
CHEMBL1988141 — Ki = 63.1 nM 7.20
CHEMBL1973359 — Ki = 79.43 nM 7.10
CHEMBL1993877 — Ki = 100.0 nM 7.00
CHEMBL1979690 — Ki = 100.0 nM 7.00
CHEMBL189963 PALBOCICLIB Ki = 100.0 nM 7.00
CHEMBL1974617 — Ki = 100.0 nM 7.00
CHEMBL189963 PALBOCICLIB Ki = 100.0 nM 7.00
CHEMBL1996702 — Ki = 100.0 nM 7.00
CHEMBL1983715 — Ki = 100.0 nM 7.00
CHEMBL1972346 — Ki = 100.0 nM 7.00
CHEMBL422897 — Ki = 125.89 nM 6.90
CHEMBL1985681 — Ki = 125.89 nM 6.90
CHEMBL1967998 — Ki = 158.49 nM 6.80
CHEMBL2000029 — Ki = 158.49 nM 6.80
CHEMBL1992937 — Ki = 158.49 nM 6.80
CHEMBL2002992 — Ki = 158.49 nM 6.80
CHEMBL1991734 — Ki = 158.49 nM 6.80
CHEMBL2007479 — Ki = 199.53 nM 6.70
CHEMBL2004515 — Ki = 251.19 nM 6.60
CHEMBL1983945 — Ki = 251.19 nM 6.60
CHEMBL1973516 — Ki = 251.19 nM 6.60