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Compound Detail

CHEMBL2017868

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CS(=O)(=O)N1CCC(Oc2ccc(CC(=O)N3CCC(N4C(=O)CCc5ccccc54)CC3)c(OC/C=C\I)c2)CC1

Basic Information

ChEMBL ID CHEMBL2017868
Phase Preclinical
Structure Type MOL
InChI Key ZJWAEMNLDJQLSS-TVPGTPATSA-N
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

707.6
MW (Da)
4.33
ALogP
6
HBA
0
HBD
96.5
PSA (Ų)
0.36
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H38IN3O6S
MW 707.63
Aromatic Rings 2
Heavy Atoms 42
NP-Likeness -0.76

Activity Summary

Ki 6 meas. best 8.38

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Oxytocin receptor
CHEMBL2016427
Ki 8.38 8.38 4.2 1
Oxytocin receptor
CHEMBL2049
Ki 8.24 8.24 5.7 1
Vasopressin V1a receptor
CHEMBL2016428
Ki 7.8 7.8 16.0 1
Vasopressin V1a receptor
CHEMBL1889
Ki 6.28 6.28 530.0 1
Vasopressin V2 receptor
CHEMBL1790
Ki 6.24 6.24 580.0 1
Vasopressin V1b receptor
CHEMBL1921
Ki 5.02 5.02 9600.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22425346 10.1016/j.bmc.2012.02.019 Oxytocin receptor 2
22425346 10.1016/j.bmc.2012.02.019 Vasopressin V1a receptor 2
22425346 10.1016/j.bmc.2012.02.019 Vasopressin V1b receptor 1
22425346 10.1016/j.bmc.2012.02.019 Vasopressin V2 receptor 1
22425346 10.1016/j.bmc.2012.02.019 No relevant target 1

Data from ChEMBL 36 via Core Engine