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Compound Detail

CHEMBL251940

PERICIAZINE
🧪 Phase II
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🧪 Phase II
N#Cc1ccc2c(c1)N(CCCN1CCC(O)CC1)c1ccccc1S2
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL251940
Name PERICIAZINE
Phase Phase II
Structure Type MOL
InChI Key LUALIOATIOESLM-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Neulactil NSC-758641 Periciazina Periciazine Pericyazine Propericiazine RP 8909 RP 8909SKF 20716 RP-8909 SKF 20716 SKF-20716
4
Targets
5
Activities
2
Assay Types
0
PK Parameters
20
Publications
11
Known Names
1
Indications

Molecular Properties

365.5
MW (Da)
4.01
ALogP
5
HBA
1
HBD
50.5
PSA (Ų)
0.89
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product

Extended Properties

Molecular Formula C21H23N3OS
MW 365.50
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.31

Indications

Psychotic Disorders

ATC Classification

N05AC01
periciazine
Level 1: NERVOUS SYSTEM
Level 2: PSYCHOLEPTICS

Activity Summary

IC50 4 meas. best 6.64
Ki 1 meas. best 5.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cholinesterase
CHEMBL5763
 IC50 6.64 6.64 230.0 1
Androgen receptor
CHEMBL3072
 Ki 5.52 5.52 3000.0 1
Plasmodium falciparum
CHEMBL364
 IC50 5.18 5.18 6562.0 1
Acetylcholinesterase
CHEMBL4768
 IC50 5.16 5.16 7000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cholinesterase IC50 = 230.0 nM 6.64 Inhibition of Equine serum BChE using butyrylthiocholine iodide as a substrate a... 21459491
Androgen receptor Ki = 3000.0 nM 5.52 Displacement of [3H]mibolerone from rat androgen receptor 17606915
Plasmodium falciparum IC50 = 6562.0 nM 5.18 Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by fi... 20547797
Acetylcholinesterase IC50 = 7000.0 nM 5.16 Inhibition of bovine erythrocyte AChE using acetylthiocholine iodide as a substr... 21459491

Literature References

PubMed DOI Target Context # Activities
- 10.5281/zenodo.13943903 ADMET 60
31158845 10.1038/s41586-019-1291-3 ADMET 55
- 10.6019/CHEMBL4651402 SARS-CoV-2 4
31158845 10.1038/s41586-019-1291-3 SGNH hydrolase-type esterase domain-containing protein 3
17606915 10.1073/pnas.0609752104 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
31158845 10.1038/s41586-019-1291-3 Nitroreductase domain-containing protein 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
31158845 10.1038/s41586-019-1291-3 Acyltransferase 2
31158845 10.1038/s41586-019-1291-3 GDSL-like protein 2
33324471 10.1021/acsmedchemlett.0c00521 Unchecked 2
- 10.6019/CHEMBL4651402 Vero C1008 2
576620 10.1021/jm00213a022 No relevant target 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
31158845 10.1038/s41586-019-1291-3 Lipolytic enzyme, G-D-S-L family 2
18027916 10.1021/jm070524a No relevant target 2
576620 10.1021/jm00213a022 Albumin 1
21459491 10.1016/j.ejmech.2011.02.071 Unchecked 1
21459491 10.1016/j.ejmech.2011.02.071 Cholinesterase 1

Data from ChEMBL 36 via Core Engine