Compound Detail
CHEMBL354349
EUFLAVINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL354349 |
| Name | EUFLAVINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KKAJSJJFBSOMGS-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1184529 |
| Active Moiety | CHEMBL1184529 |
4
Targets
7
Activities
2
Assay Types
0
PK Parameters
17
Publications
4
Known Names
Molecular Properties
224.3
MW (Da)
1.98
ALogP
2
HBA
2
HBD
55.9
PSA (Ų)
0.35
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
ATC Classification
D08AA03
euflavine
Level 1: DERMATOLOGICALS
Level 2: ANTISEPTICS AND DISINFECTANTS
Activity Summary
IC50 6 meas. best 6.0
EC50 1 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HEK293 CHEMBL614818 | EC50 | 6.24 | 6.24 | 575.8 | 1 |
| Hypoxia-inducible factor 1-alpha CHEMBL4261 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.0 | 5.34 | 1000.0 | 3 |
| Replicase polyprotein 1ab CHEMBL4523582 | IC50 | 5.3 | 5.275 | 4980.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HEK293 | EC50 | = | 575.83 | nM | 6.24 | PUBCHEM_BIOASSAY: Counterscreen for IDE activators: Fluorescence polarization-ba... | - |
| Hypoxia-inducible factor 1-alpha | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of HIF-1 dimerization in HEK293 cells after 24 hrs by renilla lucifer... | 30819620 |
| Unchecked | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of Plasmodium falciparum 3D7 Gyrase B | 38171145 |
| Unchecked | IC50 | = | 3141.0 | nM | 5.5 | PubChem BioAssay. Fluorescence-based biochemical high throughput screening dose ... | - |
| Replicase polyprotein 1ab | IC50 | = | 4980.0 | nM | 5.3 | SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response ... | - |
| Replicase polyprotein 1ab | IC50 | = | 5600.0 | nM | 5.25 | Inhibition of C-terminal GST-tagged SARS-CoV-2 Main protease by using MCA-AVLQSG... | 37244162 |
| Unchecked | IC50 | = | 30198.0 | nM | 4.52 | PubChem BioAssay. Counterscreen for inhibitors of Crimean-Congo Hemorrhagic Feve... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20498323 | 10.1128/aac.01803-09 | Burkholderia pseudomallei | 10 |
| 20660673 | 10.1128/aac.01065-09 | Staphylococcus aureus | 10 |
| 6737429 | 10.1021/jm00373a010 | Trypanosoma brucei | 9 |
| 17548499 | 10.1128/aac.00339-07 | Escherichia coli | 7 |
| 17638702 | 10.1128/aac.00072-07 | Enterobacter cloacae | 6 |
| 17576828 | 10.1128/aac.00430-07 | Staphylococcus aureus | 3 |
| 22483632 | 10.1016/j.ejmech.2012.03.008 | Escherichia coli | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| 38171145 | 10.1016/j.ejmech.2023.116056 | Unchecked | 1 |
| 2362268 | 10.1021/jm00169a014 | CHO | 1 |
| 37244162 | 10.1016/j.ejmech.2023.115491 | Replicase polyprotein 1ab | 1 |
| 30819620 | 10.1016/j.bmc.2019.01.042 | Hypoxia-inducible factor 1-alpha | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 2362268 | 10.1021/jm00169a014 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine