Compound Detail
CHEMBL463931
GSK-2163632A Enter ChEMBL ID:
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COc1cc2c(cc1Nc1nc(Nc3ccsc3C(N)=O)c3cc[nH]c3n1)N(C(=O)CN(C)C)CCC2(C)C
Basic Information
| ChEMBL ID | CHEMBL463931 |
| Name | GSK-2163632A |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YNSCKPCDFIDINW-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
1
PK Parameters
20
Publications
0
Known Names
Molecular Properties
548.7
MW (Da)
4.19
ALogP
9
HBA
4
HBD
141.5
PSA (Ų)
0.26
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Rhodopsin kinase GRK1 CHEMBL3879860 | IC50 | 6.89 | 6.89 | 130.0 | 1 |
| Beta-adrenergic receptor kinase 1 CHEMBL4079 | IC50 | 5.5 | 4.9667 | 3200.0 | 3 |
| G protein-coupled receptor kinase 5 CHEMBL5678 | IC50 | 5.5 | 5.5 | 3200.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 720.0 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 0.2 | nM | 9.7 | Inhibition of IGF1R | 19081716 |
| Rhodopsin kinase GRK1 | IC50 | = | 130.0 | nM | 6.89 | Displacement of BODIPY TR-ADP from bovine GRK1 (1 to 535 residues) preincubated ... | 31857838 |
| G protein-coupled receptor kinase 5 | IC50 | = | 3200.0 | nM | 5.5 | Displacement of BODIPY TR-ADP from GRK5 (unknown origin) preincubated for 10 min... | 31857838 |
| Beta-adrenergic receptor kinase 1 | IC50 | = | 3200.0 | nM | 5.5 | Inhibition of GRK2 (unknown origin) measured for 4 hrs | 36055000 |
| Beta-adrenergic receptor kinase 1 | IC50 | = | 20000.0 | nM | 4.7 | Displacement of BODIPY TR-ADP from human GRK2 preincubated for 10 mins followed ... | 31857838 |
| Beta-adrenergic receptor kinase 1 | IC50 | = | 20000.0 | nM | 4.7 | Inhibition of GRK2 (unknown origin) | 36055000 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase ABL1 | 14 |
| - | 10.6019/CHEMBL1961873 | Epidermal growth factor receptor | 10 |
| - | 10.6019/CHEMBL1961873 | Mast/stem cell growth factor receptor Kit | 8 |
| - | 10.6019/CHEMBL1961873 | Platelet-derived growth factor receptor alpha | 8 |
| - | 10.6019/CHEMBL1961873 | Proto-oncogene tyrosine-protein kinase receptor Ret | 6 |
| - | 10.6019/CHEMBL1961873 | Cyclin-dependent kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase B-raf | 4 |
| - | 10.6019/CHEMBL1961873 | Receptor-type tyrosine-protein kinase FLT3 | 4 |
| - | 10.6019/CHEMBL1961873 | Leucine-rich repeat serine/threonine-protein kinase 2 | 4 |
| - | 10.6019/CHEMBL1961873 | Tyrosine-protein kinase Lyn | 4 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C beta type | 4 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase D2 | 2 |
| - | 10.6019/CHEMBL1961873 | RAC-alpha serine/threonine-protein kinase | 2 |
| - | 10.6019/CHEMBL1961873 | Protein kinase C alpha type | 2 |
| - | 10.6019/CHEMBL1961873 | cAMP-dependent protein kinase catalytic subunit alpha | 2 |
| 36055000 | 10.1016/j.ejmech.2022.114668 | Beta-adrenergic receptor kinase 1 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase beta-1 | 2 |
| - | 10.6019/CHEMBL1961873 | Ribosomal protein S6 kinase alpha-5 | 2 |
| - | 10.6019/CHEMBL1961873 | Serine/threonine-protein kinase MRCK beta | 2 |
| - | 10.6019/CHEMBL1961873 | Rhodopsin kinase GRK7 | 2 |
Data from ChEMBL 36 via Core Engine