Compound Detail
CHEMBL5423441
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Basic Information
| ChEMBL ID | CHEMBL5423441 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BPINBUVFRVILJC-NTEUORMPSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
449.0
MW (Da)
5.02
ALogP
3
HBA
2
HBD
52.6
PSA (Ų)
0.46
QED
1
Ro5 Violations
10
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cholinesterase CHEMBL5763 | IC50 | 5.64 | 5.64 | 2270.0 | 1 |
| GABA transporter 2 CHEMBL4228 | IC50 | 4.96 | 4.96 | 10964.8 | 1 |
| GABA transporter 4 CHEMBL3699 | IC50 | 4.81 | 4.81 | 15488.2 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 CHEMBL5445 | IC50 | 4.79 | 4.79 | 16218.1 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.77 | 4.77 | 16982.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cholinesterase | IC50 | = | 2270.0 | nM | 5.64 | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pr... | 37837674 |
| GABA transporter 2 | IC50 | = | 10964.78 | nM | 4.96 | Inhibition of mouse GAT2 transfected in HEK293 cells assessed as reduction in [3... | 37837674 |
| GABA transporter 4 | IC50 | = | 15488.17 | nM | 4.81 | Inhibition of mouse GAT4 transfected in HEK293 cells assessed as reduction in [3... | 37837674 |
| Sodium- and chloride-dependent GABA transporter 1 | IC50 | = | 16218.1 | nM | 4.79 | Inhibition of mouse GAT1 transfected in HEK293 cells assessed as reduction in [3... | 37837674 |
| Unchecked | IC50 | = | 16982.44 | nM | 4.77 | Inhibition of mouse GAT3 transfected in HEK293 cells assessed as reduction in [3... | 37837674 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37837674 | 10.1016/j.ejmech.2023.115832 | Sodium- and chloride-dependent GABA transporter 1 | 2 |
| 37837674 | 10.1016/j.ejmech.2023.115832 | Unchecked | 2 |
| 37837674 | 10.1016/j.ejmech.2023.115832 | GABA transporter 2 | 1 |
| 37837674 | 10.1016/j.ejmech.2023.115832 | GABA transporter 4 | 1 |
| 37837674 | 10.1016/j.ejmech.2023.115832 | Acetylcholinesterase | 1 |
| 37837674 | 10.1016/j.ejmech.2023.115832 | Cholinesterase | 1 |
| 37837674 | 10.1016/j.ejmech.2023.115832 | Beta-secretase 1 | 1 |
Data from ChEMBL 36 via Core Engine