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Compound Detail

CHEMBL5794018

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CC(O)COC[C@H]1O[C@@H]2O[C@H]3[C@@H](O)[C@H](O)[C@@H](O[C@H]4[C@@H](O)[C@H](O)[C@@H](O[C@H]5[C@@H](O)[C@H](O)[C@@H](O[C@H]6[C@@H](O)[C@H](O)[C@@H](O[C@H]7[C@@H](O)[C@H](O)[C@@H](O[C@H]8[C@@H](O)[C@H](O)[C@@H](O[C@H]1[C@@H](O)[C@@H]2O)O[C@@H]8COCC(C)O)O[C@@H]7COCC(C)O)O[C@@H]6COCC(C)O)O[C@@H]5COCC(C)O)O[C@@H]4COCC(C)O)O[C@@H]3COCC(C)O

Basic Information

ChEMBL ID CHEMBL5794018
Phase Preclinical
Structure Type MOL
InChI Key ODLHGICHYURWBS-BSHKJPLBSA-N
11
Targets
11
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

1541.5
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C63H112O42
MW 1541.55

Activity Summary

IC50 11 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Histone deacetylase 3
CHEMBL1829
IC50 8.4 8.4 4.0 1
Histone deacetylase 6
CHEMBL1865
IC50 8.13 8.13 7.5 1
Histone deacetylase 1
CHEMBL325
IC50 8.06 8.06 8.7 1
Histone deacetylase 2
CHEMBL1937
IC50 7.8 7.8 15.9 1
Polyamine deacetylase HDAC10
CHEMBL5103
IC50 7.69 7.69 20.3 1
Histone deacetylase 8
CHEMBL3192
IC50 7.25 7.25 55.7 1
Histone deacetylase 5
CHEMBL2563
IC50 6.96 6.96 110.0 1
Histone deacetylase 4
CHEMBL3524
IC50 6.25 6.25 567.0 1
Histone deacetylase 9
CHEMBL4145
IC50 6.03 6.03 927.0 1
Histone deacetylase 11
CHEMBL3310
IC50 5.86 5.86 1380.0 1
Histone deacetylase 7
CHEMBL2716
IC50 5.74 5.74 1820.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine