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Evidence Snapshot

Sex hormone-binding globulin

CHEMBL3305 SINGLE PROTEIN Homo sapiens
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:46Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3305
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sex hormone-binding globulin as ChEMBL target CHEMBL3305, mapped to UniProt P04278. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sex hormone-binding globulin
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3305
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P04278
Sex hormone-binding globulin
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Sex hormone-binding globulin matters

As of 2026-09-13

Sex hormone-binding globulin is reviewed as Sex hormone-binding globulin (UniProt P04278); the current evidence base includes 17 approved drugs, 179 compounds, and 33 assays, with lead potency reaching pChEMBL 9.7.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 17 approved drugs, 179 compounds, and 33 assays for this target. The dominant activity type is KD. CHEMBL260202 is the current potency anchor at pChEMBL 9.7.

Use CHEMBL260202 as the tractability anchor when discussing potency (pChEMBL 9.7).

Activity source · ChEMBL 36 via Core Engine
17 approved pChEMBL 9.7
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Sex hormone-binding globulin matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P04278, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

179
Total Compounds
33
Total Assays
17
Approved Drugs
IC50: 14.0, KI: 1.0, KD: 92.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL260202
 9.7 Kd —
No preferred name
CHEMBL27769
 9.7 Kd Clinical
No preferred name
CHEMBL258918
 9.6 Kd Clinical
No preferred name
CHEMBL259126
 9.5 Kd —
No preferred name
CHEMBL411053
 9.4 Kd —

Approved Drugs

Structure Compound First Approval
ETONOGESTREL
CHEMBL1531
 2001
ESTRIOL
CHEMBL193482
 2000
DESOGESTREL
CHEMBL1533
 1992
ETHINYL ESTRADIOL
CHEMBL691
 1982
ESTRONE
CHEMBL1405
 1979
DANAZOL
CHEMBL1479
 1976
PROGESTERONE
CHEMBL103
 1976
ESTRADIOL
CHEMBL135
 1975
METHYLTESTOSTERONE
CHEMBL1395
 1973
TESTOSTERONE
CHEMBL386630
 1972
NORGESTREL
CHEMBL2107797
 1968
NORETHINDRONE
CHEMBL1162
 1962
MEDROXYPROGESTERONE ACETATE
CHEMBL717
 1959
HYDROCORTISONE
CHEMBL389621
 1952
PRASTERONE
CHEMBL90593
 —
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Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T22:20:46Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL3305