Assay Detail
Binding
CHEMBL1015345
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Selectivity assessed as difference in pEC50 for human cloned beta2 adrenergic receptor and pEC50 for human cloned beta3 adrenergic receptor
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 4.00 | 4.00 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446840 | — | — | 1 | 4.00 |
| CHEMBL475237 | — | — | 1 | - |
| CHEMBL475389 | — | — | 1 | - |
| CHEMBL516056 | — | — | 1 | - |
| CHEMBL474393 | — | — | 1 | - |
| CHEMBL514032 | — | — | 1 | - |
| CHEMBL500782 | — | — | 1 | - |
| CHEMBL506518 | — | — | 1 | - |
| CHEMBL456485 | — | — | 1 | - |
| CHEMBL475236 | — | — | 1 | - |
| CHEMBL485847 | — | — | 1 | - |
| CHEMBL483202 | — | — | 1 | - |
| CHEMBL483407 | — | — | 1 | - |
| CHEMBL443435 | — | — | 1 | - |
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | - |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | - |
| CHEMBL520313 | — | — | 1 | - |
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446840 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL475237 | — | EC50 | = | 630957.34 | nM | - |
| CHEMBL475389 | — | EC50 | = | 398107.17 | nM | - |
| CHEMBL516056 | — | EC50 | = | 794328.23 | nM | - |
| CHEMBL474393 | — | EC50 | = | 1584893.19 | nM | - |
| CHEMBL514032 | — | EC50 | = | 1584893.19 | nM | - |
| CHEMBL500782 | — | EC50 | = | 3981071.71 | nM | - |
| CHEMBL506518 | — | EC50 | = | 6309573.44 | nM | - |
| CHEMBL456485 | — | EC50 | = | 1995262.31 | nM | - |
| CHEMBL475236 | — | EC50 | = | 501187.23 | nM | - |
| CHEMBL485847 | — | EC50 | = | 7943282.35 | nM | - |
| CHEMBL483202 | — | EC50 | = | 3162277.66 | nM | - |
| CHEMBL483407 | — | pEC50 | - | — | - | |
| CHEMBL443435 | — | EC50 | = | 794328.23 | nM | - |
| CHEMBL1263 | SALMETEROL | EC50 | = | 199526.23 | nM | - |
| CHEMBL1256786 | FORMOTEROL | EC50 | = | 19952623.15 | nM | - |
| CHEMBL520313 | — | EC50 | = | 1584893.19 | nM | - |
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 1000000000.0 | nM | - |