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Assay Detail

CHEMBL1963702

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKG2
ChEMBL ↗
520
Total Activities
513
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

cGMP-dependent protein kinase 2 (CHEMBL2896) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 520 6.62 8.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1990254 — — 2 8.60
CHEMBL2001751 — — 1 8.40
CHEMBL1976240 — — 1 8.40
CHEMBL1991063 — — 1 8.10
CHEMBL1974870 — — 1 7.90
CHEMBL1975121 — — 1 7.80
CHEMBL592030 — — 1 7.70
CHEMBL2006188 — — 1 7.70
CHEMBL1991188 — — 1 7.70
CHEMBL1965836 — — 1 7.60
CHEMBL1682552 — — 1 7.60
CHEMBL1998159 — — 1 7.50
CHEMBL1974288 — — 1 7.50
CHEMBL220241 GSK-269962A — 1 7.40
CHEMBL1998121 — — 1 7.40
CHEMBL1682553 — — 1 7.40
CHEMBL1975900 — — 1 7.40
CHEMBL1981782 — — 1 7.40
CHEMBL2005936 — — 1 7.30
CHEMBL1999428 — — 1 7.30
CHEMBL1970217 — — 1 7.30
CHEMBL1969049 — — 1 7.10
CHEMBL225519 — — 1 7.10
CHEMBL1974935 — — 1 7.00
CHEMBL1967544 — — 1 6.90
CHEMBL2003341 — — 1 6.80
CHEMBL1993548 — — 1 6.80
CHEMBL1982711 — — 1 6.80
CHEMBL2007296 — — 1 6.80
CHEMBL1975128 — — 1 6.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1990254 — Ki = 2.512 nM 8.60
CHEMBL1990254 — Ki = 3.162 nM 8.50
CHEMBL1976240 — Ki = 3.981 nM 8.40
CHEMBL2001751 — Ki = 3.981 nM 8.40
CHEMBL1991063 — Ki = 7.943 nM 8.10
CHEMBL1974870 — Ki = 12.59 nM 7.90
CHEMBL1975121 — Ki = 15.85 nM 7.80
CHEMBL2006188 — Ki = 19.95 nM 7.70
CHEMBL592030 — Ki = 19.95 nM 7.70
CHEMBL1991188 — Ki = 19.95 nM 7.70
CHEMBL1965836 — Ki = 25.12 nM 7.60
CHEMBL1682552 — Ki = 25.12 nM 7.60
CHEMBL1998159 — Ki = 31.62 nM 7.50
CHEMBL1974288 — Ki = 31.62 nM 7.50
CHEMBL1682553 — Ki = 39.81 nM 7.40
CHEMBL1981782 — Ki = 39.81 nM 7.40
CHEMBL1975900 — Ki = 39.81 nM 7.40
CHEMBL220241 GSK-269962A Ki = 39.81 nM 7.40
CHEMBL1998121 — Ki = 39.81 nM 7.40
CHEMBL2005936 — Ki = 50.12 nM 7.30
CHEMBL1970217 — Ki = 50.12 nM 7.30
CHEMBL1999428 — Ki = 50.12 nM 7.30
CHEMBL1969049 — Ki = 79.43 nM 7.10
CHEMBL225519 — Ki = 79.43 nM 7.10
CHEMBL1974935 — Ki = 100.0 nM 7.00
CHEMBL1967544 — Ki = 125.89 nM 6.90
CHEMBL2003341 — Ki = 158.49 nM 6.80
CHEMBL1982711 — Ki = 158.49 nM 6.80
CHEMBL2007296 — Ki = 158.49 nM 6.80
CHEMBL1993548 — Ki = 158.49 nM 6.80
CHEMBL1975128 — Ki = 199.53 nM 6.70
CHEMBL1996931 — Ki = 199.53 nM 6.70
CHEMBL1988608 — Ki = 251.19 nM 6.60
CHEMBL1973540 — Ki = 316.23 nM 6.50
CHEMBL1970709 — Ki = 316.23 nM 6.50
CHEMBL1965507 — Ki = 316.23 nM 6.50
CHEMBL1965845 — Ki = 316.23 nM 6.50
CHEMBL1971943 BAY-549 Ki = 316.23 nM 6.50
CHEMBL2002726 — Ki = 398.11 nM 6.40
CHEMBL1966628 — Ki = 398.11 nM 6.40
CHEMBL1964937 — Ki = 398.11 nM 6.40
CHEMBL340384 — Ki = 398.11 nM 6.40
CHEMBL1970903 — Ki = 501.19 nM 6.30
CHEMBL1977135 — Ki = 501.19 nM 6.30
CHEMBL1983945 — Ki = 501.19 nM 6.30
CHEMBL2005886 — Ki = 501.19 nM 6.30
CHEMBL1978448 — Ki = 501.19 nM 6.30
CHEMBL1996111 — Ki = 630.96 nM 6.20
CHEMBL2004934 — Ki = 630.96 nM 6.20
CHEMBL1993722 — Ki = 630.96 nM 6.20