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Compound Detail

CHEMBL1996931

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O=C(NC(CO)Cc1ccc(Cl)cc1)c1ccc(-c2ccncc2)cc1

Basic Information

ChEMBL ID CHEMBL1996931
Phase Preclinical
Structure Type MOL
InChI Key DPPIQOOVRLCHQC-UHFFFAOYSA-N
14
Targets
14
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

366.9
MW (Da)
3.74
ALogP
3
HBA
2
HBD
62.2
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H19ClN2O2
MW 366.85
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -0.66

Activity Summary

Ki 14 meas. best 6.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Rho-associated protein kinase 2
CHEMBL2973
Ki 6.9 6.9 125.9 1
cAMP-dependent protein kinase catalytic subunit PRKX
CHEMBL5818
Ki 6.8 6.8 158.5 1
cGMP-dependent protein kinase 2
CHEMBL2896
Ki 6.7 6.7 199.5 1
cGMP-dependent protein kinase 1
CHEMBL4273
Ki 6.7 6.7 199.5 1
cAMP-dependent protein kinase catalytic subunit alpha
CHEMBL4101
Ki 6.3 6.3 501.2 1
Casein kinase I isoform gamma-1
CHEMBL2426
Ki 6.2 6.2 631.0 1
Dual specificity protein kinase CLK4
CHEMBL4203
Ki 5.9 5.9 1258.9 1
Aurora kinase B
CHEMBL2185
Ki 5.8 5.8 1584.9 1
Ribosomal protein S6 kinase beta-1
CHEMBL4501
Ki 5.8 5.8 1584.9 1
Rho-associated protein kinase 1
CHEMBL3231
Ki 5.7 5.7 1995.3 1
LIM domain kinase 1
CHEMBL3836
Ki 5.5 5.5 3162.3 1
Homeodomain-interacting protein kinase 4
CHEMBL1075167
Ki 5.1 5.1 7943.3 1
Serine/threonine-protein kinase N2
CHEMBL3032
Ki 5.1 5.1 7943.3 1
Interleukin-1 receptor-associated kinase 1
CHEMBL3357
Ki 5.1 5.1 7943.3 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Rho-associated protein kinase 2 Ki = 125.89 nM 6.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
cAMP-dependent protein kinase catalytic subunit PRKX Ki = 158.49 nM 6.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
cGMP-dependent protein kinase 1 Ki = 199.53 nM 6.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
cGMP-dependent protein kinase 2 Ki = 199.53 nM 6.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
cAMP-dependent protein kinase catalytic subunit alpha Ki = 501.19 nM 6.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Casein kinase I isoform gamma-1 Ki = 630.96 nM 6.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Dual specificity protein kinase CLK4 Ki = 1258.93 nM 5.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Ribosomal protein S6 kinase beta-1 Ki = 1584.89 nM 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Aurora kinase B Ki = 1584.89 nM 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Rho-associated protein kinase 1 Ki = 1995.26 nM 5.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
LIM domain kinase 1 Ki = 3162.28 nM 5.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Interleukin-1 receptor-associated kinase 1 Ki = 7943.28 nM 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Serine/threonine-protein kinase N2 Ki = 7943.28 nM 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -
Homeodomain-interacting protein kinase 4 Ki = 7943.28 nM 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member na... -

Data from ChEMBL 36 via Core Engine