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Assay Detail

CHEMBL1963802

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK1
ChEMBL ↗
594
Total Activities
584
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category other
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Interleukin-1 receptor-associated kinase 1 (CHEMBL3357) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 594 5.90 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1967878 CENISERTIB 2.0 1 8.00
CHEMBL475251 R-406 2.0 1 8.00
CHEMBL1994241 — — 1 7.90
CHEMBL2000345 — — 1 7.90
CHEMBL1969301 — — 1 7.80
CHEMBL210887 — — 1 7.70
CHEMBL1973540 — — 1 7.70
CHEMBL1987034 — — 1 7.60
CHEMBL1988163 — — 1 7.50
CHEMBL1971029 — — 1 7.50
CHEMBL1999931 — — 1 7.50
CHEMBL1995813 — — 1 7.40
CHEMBL2006439 — — 1 7.30
CHEMBL1969588 — — 1 7.30
CHEMBL484390 — — 1 7.30
CHEMBL1983111 — — 1 7.20
CHEMBL1974328 — — 1 7.20
CHEMBL244378 — — 1 7.10
CHEMBL1986943 — — 2 7.10
CHEMBL225519 — — 1 7.10
CHEMBL482967 CYC-116 1.0 1 7.10
CHEMBL509032 TAE-684 — 1 7.10
CHEMBL396523 — — 1 7.10
CHEMBL1965660 — — 2 7.00
CHEMBL1966628 — — 1 6.90
CHEMBL411903 — — 1 6.90
CHEMBL1976420 — — 1 6.90
CHEMBL1990885 — — 1 6.90
CHEMBL1992937 — — 1 6.90
CHEMBL1986263 — — 1 6.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1967878 CENISERTIB Ki = 10.0 nM 8.00
CHEMBL475251 R-406 Ki = 10.0 nM 8.00
CHEMBL2000345 — Ki = 12.59 nM 7.90
CHEMBL1994241 — Ki = 12.59 nM 7.90
CHEMBL1969301 — Ki = 15.85 nM 7.80
CHEMBL210887 — Ki = 19.95 nM 7.70
CHEMBL1973540 — Ki = 19.95 nM 7.70
CHEMBL1987034 — Ki = 25.12 nM 7.60
CHEMBL1988163 — Ki = 31.62 nM 7.50
CHEMBL1999931 — Ki = 31.62 nM 7.50
CHEMBL1971029 — Ki = 31.62 nM 7.50
CHEMBL1995813 — Ki = 39.81 nM 7.40
CHEMBL1969588 — Ki = 50.12 nM 7.30
CHEMBL484390 — Ki = 50.12 nM 7.30
CHEMBL2006439 — Ki = 50.12 nM 7.30
CHEMBL1983111 — Ki = 63.1 nM 7.20
CHEMBL1974328 — Ki = 63.1 nM 7.20
CHEMBL509032 TAE-684 Ki = 79.43 nM 7.10
CHEMBL482967 CYC-116 Ki = 79.43 nM 7.10
CHEMBL225519 — Ki = 79.43 nM 7.10
CHEMBL244378 — Ki = 79.43 nM 7.10
CHEMBL1986943 — Ki = 79.43 nM 7.10
CHEMBL1986943 — Ki = 79.43 nM 7.10
CHEMBL396523 — Ki = 79.43 nM 7.10
CHEMBL1965660 — Ki = 100.0 nM 7.00
CHEMBL1965660 — Ki = 100.0 nM 7.00
CHEMBL1990885 — Ki = 125.89 nM 6.90
CHEMBL1976420 — Ki = 125.89 nM 6.90
CHEMBL411903 — Ki = 125.89 nM 6.90
CHEMBL1966628 — Ki = 125.89 nM 6.90
CHEMBL1992937 — Ki = 125.89 nM 6.90
CHEMBL1986263 — Ki = 158.49 nM 6.80
CHEMBL340384 — Ki = 158.49 nM 6.80
CHEMBL1981079 — Ki = 158.49 nM 6.80
CHEMBL1978448 — Ki = 158.49 nM 6.80
CHEMBL1825138 — Ki = 199.53 nM 6.70
CHEMBL243088 — Ki = 251.19 nM 6.60
CHEMBL2003638 — Ki = 251.19 nM 6.60
CHEMBL1970903 — Ki = 251.19 nM 6.60
CHEMBL519697 — Ki = 251.19 nM 6.60
CHEMBL1971943 BAY-549 Ki = 316.23 nM 6.50
CHEMBL1964290 — Ki = 316.23 nM 6.50
CHEMBL1970104 — Ki = 316.23 nM 6.50
CHEMBL939 GEFITINIB Ki = 316.23 nM 6.50
CHEMBL1998159 — Ki = 316.23 nM 6.50
CHEMBL1988838 — Ki = 316.23 nM 6.50
CHEMBL1970104 — Ki = 316.23 nM 6.50
CHEMBL939 GEFITINIB Ki = 316.23 nM 6.50
CHEMBL1992634 — Ki = 316.23 nM 6.50
CHEMBL1236126 — Ki = 398.11 nM 6.40